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Quantitative Integration of Mode of Action Information in Dose–Response Modeling and POD Estimation for Nonmutagenic Carcinogens: A Case Study of TCDD

Environmental Health Perspectives(2023)10.1289/ehp12677Source: DataRank Database

Quantitative Integration of Mode of Action Information in Dose–Response Modeling and POD Estimation for Nonmutagenic Carcinogens: A Case Study of TCDD is a research paper published in Environmental Health Perspectives (2023). On theSindex it has a DataRank of 0.354. It has been cited 6 times, with 6 citing works in its 1-hop citation network.

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0.354DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access6 citations · 6 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE9838

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 1.08)OA: goldTopics (42)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 82%Citation Network 18%

Base Score Contribution

0.292

From this paper's citation signal

Citation Network Contribution

0.0625

From 4 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 6 citers.

Effect of per- and polyfluoroalkyl substances on neurodevelopment: Evidence-based risk assessment in the TRAEC strategy context
Environment International202413 citations105 referencesContributes 0.025
Advancing toxicity studies of per- and poly-fluoroalkyl substances (pfass) through machine learning: Models, mechanisms, and future directions
The Science of The Total Environment202431 citations179 referencesContributes 0.019
Enhanced MOA-based probabilistic dose-response assessment: Integrating alternative fitting functions and validating early-stage data extrapolation
Ecotoxicology and Environmental Safety20251 citations45 referencesContributes 0.015
Screening of estrogen receptor activity of per- and polyfluoroalkyl substances based on deep learning and in vivo assessment
Environmental Pollution20253 citations102 referencesContributes 0.014
Invited Perspective: Reference Values à la Mode of Action
Environmental Health Perspectives20230 citations10 referencesContributes 0.000

Authors (5)

Yun Zhou ORCID,Chao Ji ORCID,James E. Klaunig ORCID,Kan Shao ORCID,Qiran Chen ORCID

Live enrichment

PubMed:38157272 PMC:PMC10756338 OpenAlex:https://openalex.org/W4390414924

NIEHS NIH HHS

Grant: K25 ES030402

National Institutes of Health

Grant: 5K25ES030402-04

Quantitative dose-response characterization for liver carcinogenicity with non-mutagenic modes of action

FWCI

1.08

Citation Percentile

0.8%

Citation Trend

2023

2024

2025

2026

goldLicense: public-domain

journalhttps://doi.org/10.1289/ehp12677

publisherhttps://doi.org/10.1289/ehp12677

publisherhttps://ehp.niehs.nih.gov/doi/pdf/10.1289/EHP12677

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38157272

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/10756338

Fields of Study

Effects of Radiation ExposureCarcinogens and Genotoxicity AssessmentStatistical Methods in Clinical Trials0301 basic medicine03 medical and health sciencesHumansCarcinogensPolychlorinated DibenzodioxinsRisk AssessmentDose-Response Relationship, DrugLiver Neoplasms

MeSH Terms

Polychlorinated DibenzodioxinsCarcinogensDose-Response Relationship, DrugHumansLiver NeoplasmsRisk Assessment

Keywords

Mode of actionPoint of deliveryCarcinogenEstimationDose–response relationshipBenchmark (surveying)ToxicologyExtrapolationComputational biologyCancerComputer sciencePharmacologyMedicineBiologyStatisticsMathematicsGeneticsInternal medicinePolychlorinated DibenzodioxinsDose-Response Relationship, DrugResearchLiver NeoplasmsCarcinogensHumansRisk Assessment

Sustainable Development Goals

SDG 0: Good health and well-being