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Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells

PLoS Biology(2021)10.1371/journal.pbio.3001176Source: DataRank Database

Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells is a research paper published in PLoS Biology (2021). On theSindex it has a DataRank of 0. It has been cited 42 times.

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Open Access42 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (8 grants)OA: goldTopics (31)IDs (PubMed, PMC)Annotations (2)SDGs (1)

FAIR Checklist

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Isabel Garcı́a-Cao ORCID,Miguel M. Álvarez‐Álvarez ORCID,Marina Salvadores ORCID,Jose Espinosa‐Carrasco ORCID,Marcel McCullough ORCID

Live enrichment

PubMed:33788831 PMC:PMC8041192

H2020 European Research Council

Grant: 757700

Hypermutated tumors: insight into genome maintenance and cancer vulnerabilities provided by an extreme burden of somatic mutations

Ministerio de Ciencia, Innovación y Universidades

Grant: BFU2017-89833-P

Ministerio de Ciencia, Innovación y Universidades

Grant: PGC2018-095616-B-I00

AECC fellowship

CERCA Programme

Intramural Research Program of the National Institutes of Health, National Cancer Institute

Centres of Excellence Severo Ochoa award

ICREA Research Professor programme

goldLicense: cc-by

publisherhttps://doi.org/10.1371/journal.pbio.3001176

publisherhttps://dx.plos.org/10.1371/journal.pbio.3001176

repositoryhttps://doaj.org/article/cfacaccdda2642cca1c1b0906cd002bb

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8041192

Europe_PMChttps://europepmc.org/articles/PMC8041192

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

Cell Line, TumorHumansCarcinoma, Non-Small-Cell LungDNA DamageCytidine DeaminaseCytosine DeaminaseProteinsDNA-Binding ProteinsDNADNA ReplicationAtaxia Telangiectasia Mutated ProteinsCheckpoint Kinase 1Adenocarcinoma of Lung

Keywords

DNA ReplicationQH301-705.5ProteinsAdenocarcinoma of LungAtaxia Telangiectasia Mutated ProteinsDNACytosine DeaminaseDNA-Binding ProteinsCarcinoma, Non-Small-Cell LungCell Line, TumorCytidine DeaminaseCheckpoint Kinase 1HumansBiology (General)Research ArticleDNA Damage

Sustainable Development Goals

SDG 3: 3. Good health