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LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains

PLoS Biology(2022)10.1371/journal.pbio.3001427Source: DataRank Database

LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains is a research paper published in PLoS Biology (2022). On theSindex it has a DataRank of 0. It has been cited 27 times.

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Open Access27 citations

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Enrichment:Funding (6 grants)Impact (FWCI 1.96)OA: goldTopics (43)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Phillip C. Aoto ORCID,Robin Lorenz ORCID,Jian Wu ORCID,Sven H. Schmidt ORCID,Jascha T. Manschwetus ORCID

Live enrichment

PubMed:35192607 PMC:PMC8863276 OpenAlex:https://openalex.org/W4213439607

Michael J. Fox Foundation for Parkinson's Research

Grant: 11425

Ruth L. Kirschstein National Research Service Award NIH/National Cancer Institute

Grant: CA009523

Deutsche Forschungsgemeinschaft

Grant: HE 1818/11

National Institutes of Health

Grant: S10 OD016234

NCI NIH HHS

Grant: T32 CA009523

Otto-Braun Fund Predoctoral Fellowship

FWCI

1.96

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1371/journal.pbio.3001427

publisherhttps://doi.org/10.1371/journal.pbio.3001427

publisherhttps://dx.plos.org/10.1371/journal.pbio.3001427

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35192607

repositoryhttps://doaj.org/article/2cc122c6b3a04604858609a307766692

Fields of Study

Plant biochemistry and biosynthesisParkinson's Disease Mechanisms and TreatmentsProtein Structure and DynamicsAllosteric RegulationAllosteric SiteCatalytic DomainDeuterium Exchange MeasurementHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Mass SpectrometryMolecular Dynamics SimulationMutationProtein BindingProtein Conformation

MeSH Terms

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2Allosteric RegulationAllosteric SiteHumansMutationProtein BindingProtein ConformationMass SpectrometryCatalytic DomainDeuterium Exchange MeasurementMolecular Dynamics Simulation

Keywords

Allosteric regulationProtein kinase domainLRRK2Helix (gastropod)KinaseBiologyBiophysicsCrosstalkHydrogen–deuterium exchangeLeucine-rich repeatBiochemistryCell biologyChemistryPhysicsEnzymeMutationHydrogenGene