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SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression

PLoS Biology(2022)10.1371/journal.pbio.3001871Source: DataRank Database

SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression is a research paper published in PLoS Biology (2022). On theSindex it has a DataRank of 0. It has been cited 29 times.

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0DataRank · unranked

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Open Access29 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (19 grants)Impact (FWCI 2.80)OA: goldTopics (44)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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Authors (43)

Saskia Stenzel ORCID,Talitha Veith ORCID,Simon Schroeder ORCID,Kirstin Friedmann,Friderike Weege ORCID

Live enrichment

PubMed:36383605 PMC:PMC9710838 OpenAlex:https://openalex.org/W4309134924

BMBF NaFoUniMedCovid19

Grant: Organo-Strat (01KX2021)

BMBF

Grant: RAPID-II (01KI2006A)

BMBF

Grant: RAPID-II (01KI2006F)

BMBF

Grant: RECAST (01IK20337)

BMBF

Grant: VARIPath (01KI2021)

German Ministry of Health

Grant: Konsiliarlabor für Coronaviren and SeCoV

German Ministry of Health

Grant: Konsiliarlabor für Coronaviren und SeCoV

DFG

Grant: SFB TR84

DFG

Grant: PP 1923, GO2153/4

DFG

Grant: SFB 1449 Z02

DFG

Grant: OS143/16-1

Einstein Stiftung Berlin

Grant: EC3R

Goethe-Universität Frankfurt am Main

Grant: Goethe-Corona-Fund

BMBF

Grant: BREATH DZL 82DZL002A1

Federal State of Lower Saxony

Grant: R2N (74ZN1574)

Federal State of Lower Saxony

Grant: COFONI 3FT21

Deutsche Forschungsgemeinschaft

Grant: 273898015/SPP 1923

Innate Sensing and Restriction of Retroviruses

Freie Universität Berlin

Berlin Institute of Health

FWCI

2.80

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

goldLicense: cc-by

journalhttps://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001871&type=printable

publisherhttps://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001871&type=printable

publisherhttps://dx.plos.org/10.1371/journal.pbio.3001871

journalhttps://doi.org/10.1371/journal.pbio.3001871

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36383605

Fields of Study

SARS-CoV-2 and COVID-19 ResearchSARS-CoV-2 detection and testingViral gastroenteritis research and epidemiology0301 basic medicine03 medical and health sciencesHumansSARS-CoV-2Angiotensin-Converting Enzyme 2COVID-19Virus SheddingAntibodies, BlockingSARS-CoV-2 variants

MeSH Terms

Angiotensin-Converting Enzyme 2COVID-19SARS-CoV-2HumansVirus SheddingAntibodies, Blocking

Keywords

BiologyInfectivityPhenotypeViral replicationGeneCell cultureVirologyAlpha (finance)GeneticsCoronavirusVirusCoronavirus disease 2019 (COVID-19)Infectious disease (medical specialty)ddc:610QH301-705.5SARS-CoV-2610COVID-19Virus Shedding616HumansAngiotensin-Converting Enzyme 2Biology (General)610 Medizin und GesundheitAntibodies, BlockingResearch Article

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron

10.6084/m9.figshare.26637489.v1figshare

10.6084/m9.figshare.26637489figshare