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Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles

PLoS Biology(2023)10.1371/journal.pbio.3002339Source: DataRank Database

Diverse microtubule-targeted anticancer agents kill cells by inducing chromosome missegregation on multipolar spindles is a research paper published in PLoS Biology (2023). On theSindex it has a DataRank of 0.789. It has been cited 26 times, with 21 citing works in its 1-hop citation network.

N/A

0.789DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access26 citations · 21 citing works in its network

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Linked data & code

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Data availability

Repositories this paper deposited data in (declared in PubMed).

ClinicalTrials.govNCT03393741

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)Impact (FWCI 3.43)OA: goldTopics (36)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 63%Citation Network 37%

Base Score Contribution

0.494

From this paper's citation signal

Citation Network Contribution

0.295

From 13 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 21 citers.

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Suppressing Anaphase-Promoting Complex/Cyclosome–Cell Division Cycle 20 Activity to Enhance the Effectiveness of Anti-Cancer Drugs That Induce Multipolar Mitotic Spindles
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Evolutionary adaptation to hyperstable microtubules selectively targets tubulins and is empowered by the spindle assembly checkpoint
Cell Reports20257 citations65 referencesContributes 0.032
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Authors (9)

John B. Tucker ORCID,Christina M. Scribano ORCID,Andrew R. Lynch ORCID,Caleb L. Carlsen ORCID,Sophia T. Pop-Vicas

Live enrichment

PubMed:37883329 PMC:PMC10602348 OpenAlex:https://openalex.org/W4387954332

National Institutes of Health

Grant: P30 CA014520

National Institutes of Health

Grant: R01CA234904

National Institutes of Health

Grant: GM008688

National Institutes of Health

Grant: T32 CA009135

National Institutes of Health

Grant: F31CA254247

National Institutes of Health

Grant: T32 GM141013

NIGMS NIH HHS

Grant: T32 GM008688

NHGRI NIH HHS

Grant: T32 HG002760

National Institutes of Health

Grant: 1T32GM141013-01

Graduate Training in Molecular and Cellular Pharmacology

National Institutes of Health

Grant: 5T32GM008688-20

Training Program In Molecular AND Cellular Pharmacology

National Institutes of Health

Grant: 3T32CA009135-13S1

PREDOCTORAL TRAINING IN EXPERIMENTAL ONCOLOGY

National Institutes of Health

Grant: 5R01CA234904-03

Impact of chromosomal instability on sensitivity to microtubule-targeting drugs in breast cancer

National Institutes of Health

Grant: 1F31CA254247-01A1

Frequency and consequences of chromosome missegregation in breast cancer

National Institutes of Health

Grant: 5P30CA014520-18

CANCER CENTER SUPPORT

FWCI

3.43

Citation Percentile

0.9%

Citation Trend

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1371/journal.pbio.3002339

publisherhttps://doi.org/10.1371/journal.pbio.3002339

publisherhttps://dx.plos.org/10.1371/journal.pbio.3002339

repositoryhttps://pubmed.ncbi.nlm.nih.gov/37883329

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/10602348

Fields of Study

Microtubule and mitosis dynamicsCancer-related Molecular PathwaysUbiquitin and proteasome pathways03 medical and health sciences0302 clinical medicineHumansMicrotubulesSpindle ApparatusMitosisKinetochoresAntineoplastic AgentsPoisons

MeSH Terms

Antineoplastic AgentsHumansMicrotubulesMitosisSpindle ApparatusPoisonsKinetochores

Keywords

BiologyMicrotubuleChromosome segregationCell biologyMitosisChromosomeGeneticsGeneQH301-705.5HumansAntineoplastic AgentsSpindle ApparatusBiology (General)KinetochoresMicrotubulesPoisonsResearch Article

Sustainable Development Goals

SDG 0: Good health and well-being