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Mathematical modeling indicates that regulatory inhibition of CD8+ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load

PLoS Computational Biology(2023)10.1371/journal.pcbi.1011425Source: DataRank Database

Mathematical modeling indicates that regulatory inhibition of CD8+ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load is a research paper published in PLoS Computational Biology (2023). On theSindex it has a DataRank of 0. It has been cited 2 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access2 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (1 grants)Impact (FWCI 0.24)OA: goldTopics (29)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Amy Ellis ORCID,Shelby L. O’Connor ORCID,Elsje Pienaar ORCID,Jonathan W. Cody ORCID

Live enrichment

PubMed:37616311 OpenAlex:https://openalex.org/W4386127353

National Institutes of Health

Grant: R01AI108415

FWCI

0.24

Citation Percentile

0.5%

Citation Trend

2025

goldLicense: cc-by

journalhttps://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011425&type=printable

publisherhttps://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011425&type=printable

publisherhttps://dx.plos.org/10.1371/journal.pcbi.1011425

journalhttps://doi.org/10.1371/journal.pcbi.1011425

repositoryhttps://pubmed.ncbi.nlm.nih.gov/37616311

Fields of Study

HIV Research and TreatmentImmune Cell Function and InteractionT-cell and B-cell ImmunologyAnimalsSimian Immunodeficiency VirusInterleukin-15Viral LoadImmunotherapyCD8-Positive T-Lymphocytes

MeSH Terms

AnimalsImmunotherapySimian Immunodeficiency VirusCD8-Positive T-LymphocytesInterleukin-15Viral Load

Keywords

Simian immunodeficiency virusViral loadCD8Cytotoxic T cellImmunotherapyVirologyImmunologyImmune systemBiologyT cellViral replicationLentivirusVirusViral disease

Sustainable Development Goals

SDG 0: Good health and well-being