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Mathematical modeling suggests 14-3-3 proteins modulate RAF paradoxical activation

PLoS Computational Biology(2025)10.1371/journal.pcbi.1013297Source: DataRank Database

Mathematical modeling suggests 14-3-3 proteins modulate RAF paradoxical activation is a research paper published in PLoS Computational Biology (2025). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (16 grants)Impact (FWCI 0.00)OA: goldTopics (30)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Kodye L. Abbott ORCID,Yaocheng Li ORCID,Jingting Yu ORCID,Peter Carlip ORCID,Melinda Tong

Live enrichment

PubMed:40749078 PMC:PMC12407542 OpenAlex:https://openalex.org/W4412830521

Salk Institute for Biological Studies

Grant: Pioneer Fund

National Cancer Institute

Grant: T32CA009370

National Cancer Institute

Grant: R35CA197687

National Cancer Institute

Grant: K22CA216318

National Center for Complementary and Integrative Health

Grant: DP2AT011327

National Institutes of Health

Grant: R01GM102491

National Institutes of Health

Grant: P30CA014195

National Institutes of Health

Grant: P30AG068635

National Institutes of Health

Grant: P01AG073084

Susan G. Komen

Grant: SAC110036

Melanoma Research Alliance

Grant: 579085

Joe W. and Dorothy Dorsett Brown Foundation

Freeberg Foundation

Leona M. and Harry B. Helmsley Charitable Trust

Breast Cancer Research Foundation

The Conrad Prebys Foundation

FWCI

0.00

Citation Percentile

0.1%

goldLicense: cc-by

journalhttps://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013297&type=printable

publisherhttps://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013297&type=printable

publisherhttps://dx.plos.org/10.1371/journal.pcbi.1013297

journalhttps://doi.org/10.1371/journal.pcbi.1013297

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40749078

Fields of Study

14-3-3 protein interactionsMelanoma and MAPK PathwaysComputational Drug Discovery Methods14-3-3 Proteinsraf KinasesHumansModels, BiologicalSignal TransductionProtein Kinase InhibitorsComputational BiologyEnzyme ActivationProto-Oncogene Proteins c-raf

MeSH Terms

Enzyme ActivationHumansModels, BiologicalSignal TransductionComputational BiologyProto-Oncogene Proteins c-rafProtein Kinase Inhibitorsraf Kinases14-3-3 Proteins

Keywords

Signal transductionCell biologyProtein–protein interactionChemistryKinaseProtein kinase ABiologyBiochemistryComputational biology

Mathematical modeling suggests 14-3-3 proteins modulate RAF paradoxical activation

FAIR Checklist

Authors (11)

Funding (16 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)