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Decreased Hsp90 activity protects against TDP-43 neurotoxicity in a C. elegans model of amyotrophic lateral sclerosis

PLoS Genetics(2024)10.1371/journal.pgen.1011518Source: DataRank Database

Decreased Hsp90 activity protects against TDP-43 neurotoxicity in a C. elegans model of amyotrophic lateral sclerosis is a research paper published in PLoS Genetics (2024). On theSindex it has a DataRank of 0. It has been cited 12 times.

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Open Access12 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (10 grants)Impact (FWCI 3.44)OA: goldTopics (65)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Heather N. Currey ORCID,Joshua C. Hincks ORCID,Jade G. Stair ORCID,Nicolas J. Lehrbach ORCID,Nicole F. Liachko ORCID

Live enrichment

PubMed:39724103 OpenAlex:https://openalex.org/W4405803986

U.S. Department of Veterans Affairs

Grant: I01BX004044

National Institute on Aging

Grant: R01AG066729

National Institute of Health

Grant: R35GM142728

National Institutes of Health

Grant: 5I01BX004044-04

Investigating calcineurin regulation of pathological TDP-43 phosphorylation in ALS

National Institutes of Health

Grant: 1R01AG066729-01A1

TDP-43 in Alzheimer's disease

National Institutes of Health

Grant: 5R35GM142728-05

Regulation of Proteasome Capacity

National Institutes of Health

Grant: 1P40OD010440-01

Caenorhabditis Genetics Center

NIH HHS

Grant: P40 OD010440

BLRD VA

Grant: I01 BX005762

NIDDK NIH HHS

Grant: P30 DK017047

FWCI

3.44

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011518&type=printable

publisherhttps://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011518&type=printable

publisherhttps://dx.plos.org/10.1371/journal.pgen.1011518

journalhttps://doi.org/10.1371/journal.pgen.1011518

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39724103

Fields of Study

Amyotrophic Lateral Sclerosis ResearchGenetics, Aging, and Longevity in Model OrganismsEndoplasmic Reticulum Stress and Disease0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsCaenorhabditis elegansAmyotrophic Lateral SclerosisHSP90 Heat-Shock ProteinsDisease Models, AnimalDNA-Binding ProteinsCaenorhabditis elegans ProteinsHumansPhosphorylationMutationHeat-Shock ResponseTDP-43 Proteinopathies

MeSH Terms

Amyotrophic Lateral SclerosisAnimalsDisease Models, AnimalDNA-Binding ProteinsHumansMutationPhosphorylationCaenorhabditis elegansHSP90 Heat-Shock ProteinsHeat-Shock ResponseCaenorhabditis elegans ProteinsTDP-43 Proteinopathies

Keywords

Amyotrophic lateral sclerosisBiologyNeurodegenerationNeurotoxicityNeuroprotectionHeat shock proteinHsp90Chaperone (clinical)TARDBPCell biologyProtein aggregationHsp70MutationMutantGeneticsGeneNeuroscienceSOD1ToxicityDiseaseMedicinePathologyInternal medicineQH426-470DNA-Binding ProteinsDisease Models, AnimalTDP-43 ProteinopathiesAnimalsHumansHSP90 Heat-Shock ProteinsPhosphorylationCaenorhabditis elegansCaenorhabditis elegans ProteinsHeat-Shock ResponseResearch Article

Sustainable Development Goals

SDG 0: Good health and well-being