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Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis

PLoS Medicine(2022)10.1371/journal.pmed.1003897Source: DataRank Database

Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis is a research paper published in PLoS Medicine (2022). On theSindex it has a DataRank of 0.639. It has been cited 70 times.

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0.639DataRank · unranked

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Open Access70 citations

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Enrichment:Funding (28 grants)OA: goldTopics (62)IDs (PubMed, PMC)Annotations (3)SDGs (2)

FAIR Checklist

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 100%Citation Network 0%

Base Score Contribution

0.639

From this paper's citation signal

Citation Network Contribution

Citation network not refreshed for this result

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Authors (23)

Virginia Díez‐Obrero ORCID,Tom G. Richardson ORCID,Marie Pigeyre ORCID,Jennifer Sjaarda,Guillaume Paré ORCID

Live enrichment

PubMed:35113855 PMC:PMC8812899

Medical Research Council

Grant: MC_UU_00011/3

Statistical Methods for Improving Causal Analyses

NCI NIH HHS

Grant: UG1 CA189974

Cancer Research UK

Grant: 29019

NCI NIH HHS

Grant: R01 CA204279

NCI NIH HHS

Grant: U19 CA203654

NCI NIH HHS

Grant: UM1 CA182883

Diabetes UK

Grant: 17/0005587

Cancer Research UK

Grant: 28534

Cancer Research UK

Grant: C18281/A29019

National Institute for Health Research (NIHR)

Grant: NIHR202411

NCI NIH HHS

Grant: R01 CA143237

Medical Research Council

Grant: MC_UU_00011/1

Mendelian randomization to hypothesis-free causal inference

Medical Research Council

Grant: MC_UU_00011/4

Data mining epidemiological relationships: integration of causal analysis with published evidence

NCI NIH HHS

Grant: U01 CA182883

NCI NIH HHS

Grant: R01 CA244588

Medical Research Council

Grant: MC_UU_00011/6

Reproductive and cardio-metabolic health

Cancer Research UK

Grant: C68933/A28534

NCI NIH HHS

Grant: R33 CA094304

Wellcome Trust

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5R01CA204279-04

Biology of colorectal cancer risk enhancers

National Institutes of Health

Grant: 1R01CA201407-01A1

Using functional genomics to inform gene environment interactions for colorectal cancer

National Institutes of Health

Grant: 2R01CA143237-06A1

Inherited colorectal cancer risk variants: from association to biology

National Institutes of Health

Grant: 5U01CA167551-11

Colon Cancer Family Registry Cohort

National Institutes of Health

Grant: 5U19CA203654-04

Integrative analysis of lung cancer etiology and risk

Wellcome Trust

National Institute for Health Research (NIHR)

Wellcome Trust

Department of Health

goldLicense: cc-by

publisherhttps://doi.org/10.1371/journal.pmed.1003897

publisherhttps://dx.plos.org/10.1371/journal.pmed.1003897

https://pure.au.dk/portal/en/publications/0557a58f-fabf-43cd-a18c-672119976ad6

repositoryhttps://research-information.bris.ac.uk/en/publications/a7441032-bfed-4cd4-af04-1f160ae914e7

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8812899

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciencesAntihypertensive AgentsBlood PressureFemaleGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisNeoplasmsPeptidyl-Dipeptidase APolymorphism, Single NucleotideReceptors, Adrenergic, beta-1Risk FactorsSolute Carrier Family 12, Member 3

MeSH Terms

HumansNeoplasmsPeptidyl-Dipeptidase AReceptors, Adrenergic, beta-1Antihypertensive AgentsRisk FactorsBlood PressurePolymorphism, Single NucleotideFemaleMaleGenome-Wide Association StudyMendelian Randomization AnalysisSolute Carrier Family 12, Member 3

Keywords

Male610Mendelian Randomization Analysis/methodsPeptidyl-Dipeptidase A/geneticsBlood PressurePeptidyl-Dipeptidase AReceptors, Adrenergic, beta-1/geneticsPolymorphism, Single NucleotideBlood Pressure/drug effects/dk/atira/pure/core/keywords/icepRisk FactorsNeoplasmsHumansSolute Carrier Family 12, Member 3CàncerAntihypertensive Agents/dk/atira/pure/core/keywords/icep; name=ICEPCancerPolymorphism, Single Nucleotide/drug effectsname=ICEPAntihypertensive Agents/adverse effectsRMendelian Randomization AnalysisNeoplasms/chemically inducedHypertensionGenome-Wide Association Study/methodsMedicineHipertensióFemaleSolute Carrier Family 12, Member 3/geneticsReceptors, Adrenergic, beta-1Research ArticleGenome-Wide Association Study

Sustainable Development Goals

SDG 3: 3. Good healthSDG 16: 16. Peace & justice

Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis

FAIR Checklist

DataRank Breakdown

Authors (23)

Funding (28 grants)

Open Access

Topics

Annotations (Europe PMC)