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Dihydroartemisinin–piperaquine plus sulfadoxine–pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda

PLoS Medicine(2025)10.1371/journal.pmed.1004582Source: DataRank Database

Dihydroartemisinin–piperaquine plus sulfadoxine–pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda is a research paper published in PLoS Medicine (2025). On theSindex it has a DataRank of 0.458. It has been cited 11 times, with 6 citing works in its 1-hop citation network.

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0.458DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access11 citations · 6 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

ClinicalTrials.govNCT04336189

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 11.37)OA: goldTopics (126)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 81%Citation Network 19%

Base Score Contribution

0.373

From this paper's citation signal

Citation Network Contribution

0.0854

From 3 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 6 citers.

Beyond malaria: can intermittent preventive treatment with sulphadoxine-pyrimethamine reduce the number of small vulnerable newborns globally?
The Lancet Global Health20256 citations35 referencesContributes 0.056
Malaria in pregnancy at the frontline: a delicate balance
Current Opinion in Immunology20265 citations75 referencesContributes 0.024
Sustained High Prevalence of Multiple Antimalarial Drug Resistance Markers in Uganda in 2023-24
medRxiv20261 citations33 referencesContributes 0.021
A need for new tools for prevention of malaria in pregnancy
PLoS Medicine20250 citations11 referencesContributes 0.000
Is Seasonal Malaria Chemoprevention With Sulfadoxine-Pyrimethamine/Amodiaquine Appropriate in East Africa?
Clinical Infectious Diseases20250 citations26 referencesContributes 0.000

Authors (19)

Jimmy Kizza ORCID,Miriam Aguti ORCID,Harriet Adrama,John Ategeka ORCID,Peter Olwoch ORCID

Live enrichment

PubMed:40966190 PMC:PMC12445490 OpenAlex:https://openalex.org/W4414325352

Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Grant: U01AI141308

NIAID NIH HHS

Grant: K24 AI188458

NIAID NIH HHS

Grant: T32 AI007641

NIAID NIH HHS

Grant: K08 AI141728

Wellcome Trust

Grant: unidentified

unidentified

National Institutes of Health

Grant: 1U01AI141308-01A1

Optimal chemopreventive regimens to prevent malaria and improve birth outcomes in Uganda

FWCI

11.37

Citation Percentile

1.0%

Influential Citations

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1371/journal.pmed.1004582

GOLDhttps://doi.org/10.1371/journal.pmed.1004582

publisherhttps://doi.org/10.1371/journal.pmed.1004582

publisherhttps://dx.plos.org/10.1371/journal.pmed.1004582

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40966190

Fields of Study

Malaria Research and ControlPregnancy and preeclampsia studiesParasites and Host InteractionsMedicine0302 clinical medicine03 medical and health sciencesHumansFemalePregnancyPyrimethamineSulfadoxineQuinolinesArtemisininsDrug CombinationsDouble-Blind MethodAntimalarialsUgandaAdultPregnancy Complications, ParasiticDrug Therapy, CombinationYoung AdultAdolescentInfant, NewbornMalaria, FalciparumMalariaPregnancy OutcomePiperazines

MeSH Terms

AdolescentAdultAntimalarialsDouble-Blind MethodDrug CombinationsDrug Therapy, CombinationFemaleHumansInfant, NewbornMalariaPiperazinesPregnancyPregnancy OutcomePyrimethamineQuinolinesSulfadoxineUgandaPregnancy Complications, ParasiticMalaria, FalciparumArtemisininsYoung Adult

Keywords

MalariaDrugClinical trialProguanilChloroquinePopulationIncidence (geometry)Drug trialPrevention (rcdc)Piperazines (mesh)Women's Health (rcdc)Malaria (rcdc)Reproductive health and childbirth (hrcs-hc)Low Birth Weight and Health of the Newborn (rcdc)11 Medical and Health Sciences (for)Artemisinins (mesh)Clinical Research (rcdc)Quinolines (mesh)Pregnancy Outcome (mesh)PregnancyAntimalarials (mesh)UgandaMalaria, Falciparum32 Biomedical and Clinical Sciences (for-2020)Humans (mesh)Young Adult (mesh)3 Good Health and Well Being (sdg)Pregnancy OutcomeCombination (mesh)Malaria (mesh)Sulfadoxine (mesh)ArtemisininsDrug CombinationsPyrimethamineNewborn (mesh)QuinolinesFemaleDrug Therapy, CombinationUganda (mesh)Research ArticleAdultPerinatal Period - Conditions Originating in Perinatal Period (rcdc)General & Internal Medicine (science-metrix)AdolescentClinical Trials and Supportive Activities (rcdc)Falciparum (mesh)Maternal Health (rcdc)Comparative Effectiveness Research (rcdc)Antimicrobial Resistance (rcdc)Rare Diseases (rcdc)Conditions Affecting the Embryonic and Fetal Periods (rcdc)Drug Combinations (mesh)AntimalarialsYoung AdultPyrimethamine (mesh)Drug TherapyDouble-Blind MethodPreterm42 Health sciences (for-2020)SulfadoxineHumans3207 Medical Microbiology (for-2020)Double-Blind Method (mesh)Pediatric (rcdc)Parasitic (mesh)3202 Clinical Sciences (for-2020)6.1 Pharmaceuticals (hrcs-rac)Adolescent (mesh)Infant, NewbornInfantVector-Borne Diseases (rcdc)Infant Mortality (rcdc)Pregnancy ComplicationsPregnancy (mesh)Infectious Diseases (rcdc)Female (mesh)Pregnancy Complications, ParasiticAdult (mesh)

Related Papers (1)

Effectiveness of sulfadoxine–pyrimethamine plus amodiaquine and dihydroartemisinin–piperaquine for seasonal malaria chemoprevention in Uganda: a three-arm, open-label, non-inferiority and superiority, cluster-randomised, controlled trial

N/A

0.546DataRank · unranked

The Lancet Infectious Diseases(2025)

co-cited

10.1016/s1473-3099(24)00746-1

Dihydroartemisinin–piperaquine plus sulfadoxine–pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (19)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)

Related Papers (1)