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S. mansoni SmKI-1 Kunitz-domain: Leucine point mutation at P1 site generates enhanced neutrophil elastase inhibitory activity

PLoS neglected tropical diseases(2021)10.1371/journal.pntd.0009007Source: DataRank Database

S. mansoni SmKI-1 Kunitz-domain: Leucine point mutation at P1 site generates enhanced neutrophil elastase inhibitory activity is a research paper published in PLoS neglected tropical diseases (2021). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Scored on demand from live citation data

Open Access8 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 1.21)OA: goldTopics (41)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Bruno de Paula Oliveira Santos ORCID,Suellen B. Morais ORCID,Enrico G. T. Gimenez ORCID,Duana C. dos S. Astoni ORCID,Amanda Dias Braga ORCID

Live enrichment

PubMed:33465126 PMC:PMC7846107 OpenAlex:https://openalex.org/W3122753864

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Grant: 465229/2014-0

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Grant: 302660/2015- 1

Fundação de Amparo à Pesquisa do Estado de São Paulo

Grant: 2017/24832-6

Fundação de Amparo à Pesquisa do Estado de Minas Gerais

Grant: REDE-00140-16

National Institutes of Health

Grant: R01 AI116453

Pró-Reitoria de Pesquisa, Universidade Federal de Minas Gerais

FWCI

1.21

Citation Percentile

0.7%

Citation Trend

2021

2022

2024

2025

goldLicense: cc-by

journalhttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0009007&type=printable

GOLDhttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0009007&type=printable

publisherhttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0009007&type=printable

publisherhttps://dx.plos.org/10.1371/journal.pntd.0009007

journalhttps://doi.org/10.1371/journal.pntd.0009007

Fields of Study

Parasites and Host InteractionsResearch on Leishmaniasis StudiesSignaling Pathways in DiseaseMedicineBiology

MeSH Terms

AnimalsArthritisLeucineNeutrophilsRecombinant ProteinsSchistosoma mansoniStructure-Activity RelationshipSubstrate SpecificityPoint MutationLeukocyte ElastaseToll-Like Receptor 4MiceProteinase Inhibitory Proteins, SecretoryTranscriptomeMolecular Docking Simulation

Keywords

Point mutationMolecular biologyBinding siteElastaseIn vitroBiochemistryNeutrophil elastaseSerineAlaninePancreatic elastaseSite-directed mutagenesisDocking (animal)CysteineIn vivoChemistryBiologyMutantAmino acidEnzymeImmunologyInflammation

S. mansoni SmKI-1 Kunitz-domain: Leucine point mutation at P1 site generates enhanced neutrophil elastase inhibitory activity

FAIR Checklist

Authors (10)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)