Heterologous Stop Codon Readthrough of Metazoan Readthrough Candidates in Yeast is a research paper published in PLoS ONE (2013). On theSindex it has a DataRank of 0.440. It has been cited 8 times, with 3 citing works in its 1-hop citation network.
Recent analysis of genomic signatures in mammals, flies, and worms indicates that functional translational stop codon readthrough is considerably more abundant in metazoa than previously recognized, but this analysis provides only limited clues about the function or mechanism of readthrough. If an mRNA known to be read through in one species is also read through in another, perhaps these questions can be studied in a simpler setting. With this end in mind, we have investigated whether some of the readthrough genes in human, fly, and worm also exhibit readthrough when expressed in S. cerevisiae. We found that readthrough was highest in a gene with a post-stop hexamer known to trigger readthrough, while other metazoan readthrough genes exhibit borderline readthrough in S. cerevisiae.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.330
From this paper's citation signal
Citation Network Contribution
0.110
From 3 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 75% comes from its base citations and 25% from the citation network (3 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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