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An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity

PLoS ONE(2020)10.1371/journal.pone.0235925Source: DataRank Database

An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity is a research paper published in PLoS ONE (2020). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Open Access8 citations

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Enrichment:Funding (3 grants)Impact (FWCI 0.65)OA: goldTopics (62)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Chloe E. Kellum,Rachel J. Orlomoski,Feston Idrizi ORCID,Donald E. Spratt ORCID,Steven Beasley ORCID

Live enrichment

PubMed:32639967 PMC:PMC7343168 OpenAlex:https://openalex.org/W2769475975

National Institute of General Medical Sciences

Grant: R15GM126432

Clark University

Grant: Start-up Funds

National Institutes of Health

Grant: 2R15GM126432-02

Structure and Mechanism of HERC5-dependent ISGylation

FWCI

0.65

Citation Percentile

0.7%

Citation Trend

2020

2022

2023

2025

2026

goldLicense: cc-by

journalhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235925&type=printable

GOLDhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235925&type=printable

publisherhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235925&type=printable

publisherhttps://dx.plos.org/10.1371/journal.pone.0235925

journalhttps://doi.org/10.1371/journal.pone.0235925

Fields of Study

Genetic Syndromes and ImprintingGenetics and Neurodevelopmental DisordersRNA modifications and cancerChemistryMedicineBiology0301 basic medicine0303 health sciences03 medical and health sciencesAngelman SyndromeBiocatalysisCircular DichroismHumansMutagenesis, Site-DirectedNuclear Magnetic Resonance, BiomolecularProtein DomainsProtein StabilityProtein Structure, SecondaryRecombinant ProteinsUbiquitinUbiquitin-Protein LigasesUbiquitination

MeSH Terms

Protein DomainsCircular DichroismHumansRecombinant ProteinsMutagenesis, Site-DirectedAngelman SyndromeProtein Structure, SecondaryNuclear Magnetic Resonance, BiomolecularUbiquitinUbiquitin-Protein LigasesUbiquitinationBiocatalysisProtein Stability

Keywords

UBE3AUbiquitin ligaseUbiquitinBiologyMutationChemistryGeneticsCell biologyBiochemistryGeneProtein StabilityScienceCircular DichroismUbiquitin-Protein LigasesQRUbiquitinationProtein Structure, SecondaryRecombinant ProteinsProtein DomainsBiocatalysisMutagenesis, Site-DirectedMedicineHumansAngelman SyndromeNuclear Magnetic Resonance, BiomolecularResearch Article

Sustainable Development Goals

SDG 0: Good health and well-being

An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity

FAIR Checklist

Authors (5)

Funding (3 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)