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Enhancer polymorphisms at the IKZF1 susceptibility locus for acute lymphoblastic leukemia impact B-cell proliferation and differentiation in both Down syndrome and non-Down syndrome genetic backgrounds

PLoS ONE(2021)10.1371/journal.pone.0244863Source: DataRank Database

Enhancer polymorphisms at the IKZF1 susceptibility locus for acute lymphoblastic leukemia impact B-cell proliferation and differentiation in both Down syndrome and non-Down syndrome genetic backgrounds is a research paper published in PLoS ONE (2021). On theSindex it has a DataRank of 0. It has been cited 5 times.

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Open Access5 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)Impact (FWCI 0.76)OA: goldTopics (90)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Jacob J. Junco ORCID,Maci Terrell,Raushan Rashid,Karen R. Rabin ORCID,Vincent U. Gant ORCID

Live enrichment

PubMed:33411777 PMC:PMC7790404 OpenAlex:https://openalex.org/W3120982925

Cancer Prevention and Research Institute of Texas

Grant: RP170074

NCI NIH HHS

Grant: P30 CA125123

NCRR NIH HHS

Grant: S10 RR024574

National Institutes of Health

Grant: 1S10RR024574-01A1

BD Biosciences Special Order LSRII

National Institutes of Health

Grant: 3P30CA125123-09S3

Baylor College of Medicine Cancer Center

Lynch family

FWCI

0.76

Citation Percentile

0.7%

Citation Trend

2022

2024

2026

goldLicense: cc-by

journalhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244863&type=printable

publisherhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0244863&type=printable

publisherhttps://dx.plos.org/10.1371/journal.pone.0244863

journalhttps://doi.org/10.1371/journal.pone.0244863

repositoryhttps://pubmed.ncbi.nlm.nih.gov/33411777

Fields of Study

Acute Lymphoblastic Leukemia researchEpigenetics and DNA MethylationDNA Repair Mechanisms0301 basic medicine03 medical and health sciences0303 health sciencesAllelesAnimalsB-LymphocytesCell DifferentiationCell Line, TumorCell ProliferationDNA-Binding ProteinsDown SyndromeGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHEK293 CellsHematopoietic Stem CellsHomozygoteHumansIkaros Transcription FactorMicePolymorphism, Single NucleotidePrecursor Cell Lymphoblastic Leukemia-LymphomaQuantitative Trait LociRegulatory Sequences, Nucleic Acid

MeSH Terms

AllelesAnimalsB-LymphocytesCell DifferentiationDNA-Binding ProteinsDown SyndromeGene FrequencyGenotypeHematopoietic Stem CellsHomozygoteHumansRegulatory Sequences, Nucleic AcidGenetic Predisposition to DiseasePolymorphism, Single NucleotideQuantitative Trait LociCell Line, TumorCell ProliferationMiceIkaros Transcription FactorPrecursor Cell Lymphoblastic Leukemia-LymphomaGenome-Wide Association StudyHEK293 Cells

Keywords

BiologyAlleleLocus (genetics)LymphoblastEnhancerGeneticsDown syndromeHaematopoiesisLeukemiaImmunologyMolecular biologyCancer researchStem cellCell cultureGeneGene expressionGenotypeSciencePolymorphism, Single NucleotideIkaros Transcription FactorMiceGene FrequencyCell Line, TumorAnimalsHumansGenetic Predisposition to DiseaseAllelesCell ProliferationB-LymphocytesQHomozygoteRCell DifferentiationPrecursor Cell Lymphoblastic Leukemia-LymphomaHematopoietic Stem CellsDNA-Binding ProteinsHEK293 CellsMedicineResearch ArticleGenome-Wide Association Study

Sustainable Development Goals

SDG 2: 2. Zero hungerSDG 0: Good health and well-being

Enhancer polymorphisms at the IKZF1 susceptibility locus for acute lymphoblastic leukemia impact B-cell proliferation and differentiation in both Down syndrome and non-Down syndrome genetic backgrounds

FAIR Checklist

Authors (5)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)