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Vitamin D3 attenuates doxorubicin-induced senescence of human aortic endothelial cells by upregulation of IL-10 via the pAMPKα/Sirt1/Foxo3a signaling pathway

PLoS ONE(2021)10.1371/journal.pone.0252816Source: DataRank Database

Vitamin D3 attenuates doxorubicin-induced senescence of human aortic endothelial cells by upregulation of IL-10 via the pAMPKα/Sirt1/Foxo3a signaling pathway is a research paper published in PLoS ONE (2021). On theSindex it has a DataRank of 0. It has been cited 31 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access31 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 4.24)OA: goldTopics (57)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Rachel Holder ORCID,Charles Porter ORCID,Zubair Shah ORCID,Lei Chen ORCID

Live enrichment

PubMed:34101754 PMC:PMC8186764 OpenAlex:https://openalex.org/W3168457344

NIGMS NIH HHS

Grant: P30 GM103326

NIGMS NIH HHS

Grant: P30 GM122731

National Institutes of Health

Grant: 1P30GM103326-01A1

Flow Cytometry Core: Core 2

National Institutes of Health

Grant: 1P30GM122731-01

Molecular Regulation of Cell Development and Differentiation Phase III COBRE

The Cray Foundation Endowment

FWCI

4.24

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0252816&type=printable

GOLDhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0252816&type=printable

publisherhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0252816&type=printable

publisherhttps://dx.plos.org/10.1371/journal.pone.0252816

journalhttps://doi.org/10.1371/journal.pone.0252816

Fields of Study

Chemotherapy-induced cardiotoxicity and mitigationAntioxidant Activity and Oxidative StressAtherosclerosis and Cardiovascular DiseasesMedicine0301 basic medicine03 medical and health sciences

MeSH Terms

Forkhead Box Protein O3Antibiotics, AntineoplasticAortaCells, CulturedCholecalciferolDoxorubicinHumansProteinsVitaminsSignal TransductionUp-RegulationGene ExpressionInterleukin-10Cellular SenescenceEndothelial CellsAMP-Activated Protein KinasesSirtuin 1Primary Cell Culture

Keywords

Downregulation and upregulationDoxorubicinSenescenceCancer researchVitamin D and neurologyMedicineSirtuin 1PharmacologyEndocrinologyInternal medicineBiologyChemotherapyBiochemistrySciencePrimary Cell CultureGene ExpressionAMP-Activated Protein KinasesHumansAortaCells, CulturedCellular SenescenceCholecalciferolAntibiotics, AntineoplasticQForkhead Box Protein O3REndothelial CellsProteinsVitaminsInterleukin-10Up-RegulationResearch ArticleSignal Transduction

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being