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Bergamottin a CYP3A inhibitor found in grapefruit juice inhibits prostate cancer cell growth by downregulating androgen receptor signaling and promoting G0/G1 cell cycle block and apoptosis

PLoS ONE(2021)10.1371/journal.pone.0257984Source: DataRank Database

Bergamottin a CYP3A inhibitor found in grapefruit juice inhibits prostate cancer cell growth by downregulating androgen receptor signaling and promoting G0/G1 cell cycle block and apoptosis is a research paper published in PLoS ONE (2021). On theSindex it has a DataRank of 0. It has been cited 10 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access10 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 1.52)OA: goldTopics (56)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Priyatham Gorjala ORCID,Oscar B. Goodman ORCID,Ranjana Mitra ORCID,Opalina Vetrichelvan

Live enrichment

PubMed:34570813 PMC:PMC8476002 OpenAlex:https://openalex.org/W3202364969

National Institutes of Health

Grant: 5P20GM121325 pilot subaward

NIGMS NIH HHS

Grant: P20 GM121325

National Institutes of Health

Grant: 3P20GM121325-03S1

Microglial gene regulation and phagocytosis in prodromal Alzheimer's Disease

Roseman University of Health Science

FWCI

1.52

Citation Percentile

0.8%

Citation Trend

2022

2023

2024

2025

goldLicense: cc-by

journalhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0257984&type=printable

publisherhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0257984&type=printable

publisherhttps://dx.plos.org/10.1371/journal.pone.0257984

journalhttps://doi.org/10.1371/journal.pone.0257984

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34570813

Fields of Study

Pharmacogenetics and Drug MetabolismEstrogen and related hormone effectsProstate Cancer Treatment and Research0301 basic medicine03 medical and health sciences

MeSH Terms

Fruit and Vegetable JuicesAntineoplastic AgentsCell FractionationHumansMaleProstatic NeoplasmsFurocoumarinsReceptors, AndrogenBlotting, WesternDown-RegulationResting Phase, Cell CycleG1 PhaseApoptosisMicroscopy, ConfocalCitrus paradisiCell Line, TumorAndrogen Receptor AntagonistsCytochrome P-450 CYP3A Inhibitors

Keywords

Prostate cancerAndrogen receptorCancer researchCancerCell cycleCell growthMedicineBiologyPharmacologyInternal medicineBiochemistryMaleScienceBlotting, WesternDown-RegulationAntineoplastic AgentsApoptosisCell FractionationResting Phase, Cell CycleCell Line, TumorFurocoumarinsAndrogen Receptor AntagonistsHumansMicroscopy, ConfocalQRG1 PhaseProstatic NeoplasmsFruit and Vegetable JuicesReceptors, AndrogenCytochrome P-450 CYP3A InhibitorsResearch ArticleCitrus paradisi

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being