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Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes

PLoS ONE(2022)10.1371/journal.pone.0266017Source: DataRank Database

Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes is a research paper published in PLoS ONE (2022). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)Impact (FWCI 0.08)OA: goldTopics (60)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Taylor J. Geddes,Maria Ochiai,Noah M. Lampl,W. Wade Kothmann,Sara Fierstein ORCID

Live enrichment

PubMed:35325006 PMC:PMC8947257 OpenAlex:https://openalex.org/W4221119881

national institutes of health

Grant: 2R15CA152907-02

Tpl2 in carcinogenesis-related inflammation

NCI NIH HHS

Grant: R15 CA152907

FWCI

0.08

Citation Percentile

0.4%

Citation Trend

2025

goldLicense: cc-by

journalhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0266017&type=printable

publisherhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0266017&type=printable

publisherhttps://dx.plos.org/10.1371/journal.pone.0266017

journalhttps://doi.org/10.1371/journal.pone.0266017

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35325006

Fields of Study

Melanoma and MAPK PathwaysInfectious Diseases and MycologyPI3K/AKT/mTOR signaling in cancer0301 basic medicine0303 health sciences03 medical and health sciencesAnimalsCarcinogenesisCarcinoma, Squamous CellErbB ReceptorsHumansKeratinocytesMAP Kinase Kinase KinasesMicePapillomaProtein Kinase InhibitorsProto-Oncogene ProteinsSkin Neoplasms

MeSH Terms

AnimalsCarcinoma, Squamous CellHumansPapillomaProto-Oncogene ProteinsSkin NeoplasmsKeratinocytesMAP Kinase Kinase KinasesProtein Kinase InhibitorsMiceCarcinogenesisErbB Receptors

Keywords

Cancer researchCarcinogenesisEpidermal growth factor receptorEGFR inhibitorsBiologySkin cancerMAPK/ERK pathwayHRASSignal transductionKinaseCancerCell biologyKRASGeneticsKeratinocytesSkin NeoplasmsPapillomaScienceQRMAP Kinase Kinase KinasesErbB ReceptorsMiceProto-Oncogene ProteinsCarcinoma, Squamous CellMedicineAnimalsHumansProtein Kinase InhibitorsResearch Article

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes

FAIR Checklist

Authors (8)

Funding (2 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)