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Structure-function relationships of cholesterol mobilization from the endo-lysosome compartment of NPC1-deficient human cells by β-CD polyrotaxanes

PLoS ONE(2022)10.1371/journal.pone.0268613Source: DataRank Database

Structure-function relationships of cholesterol mobilization from the endo-lysosome compartment of NPC1-deficient human cells by β-CD polyrotaxanes is a research paper published in PLoS ONE (2022). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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Enrichment:Funding (6 grants)Impact (FWCI 0.22)OA: goldTopics (50)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Debosreeta Bose ORCID,Bradley P. Loren,Joseph L. Skulsky,Olga Ilnytska ORCID,Zachary J. Struzik ORCID

Live enrichment

PubMed:36584173 PMC:PMC9803220 OpenAlex:https://openalex.org/W4313316071

National Institute of General Medical Sciences

Grant: GM115866

National Center for Research Resources

Grant: S10DO20029

NIH HHS

Grant: S10 OD020029

NIGMS NIH HHS

Grant: R01 GM115866

National Institutes of Health

Grant: 5R01GM115866-02

Mechanisms of Cholesterol Transport by NPC Proteins

Ara Parseghian Medical Research Foundation

FWCI

0.22

Citation Percentile

0.5%

Citation Trend

2024

2025

goldLicense: cc-by

journalhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0268613&type=printable

GOLDhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0268613&type=printable

publisherhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0268613&type=printable

publisherhttps://dx.plos.org/10.1371/journal.pone.0268613

journalhttps://doi.org/10.1371/journal.pone.0268613

Fields of Study

Lysosomal Storage Disorders ResearchCarbohydrate Chemistry and SynthesisHIV Research and TreatmentMedicineChemistry0301 basic medicine0303 health sciences03 medical and health sciencesHumans2-Hydroxypropyl-beta-cyclodextrinRotaxanesCholesterolLysosomesStructure-Activity RelationshipNiemann-Pick Disease, Type CNiemann-Pick C1 Protein

MeSH Terms

2-Hydroxypropyl-beta-cyclodextrinNiemann-Pick C1 ProteinCholesterolHumansLysosomesStructure-Activity RelationshipRotaxanesNiemann-Pick Disease, Type C

Keywords

NPC1EndosomeCholesterolChemistryLysosomeCytotoxicityBiophysicsBiochemistryEndocytosisCell biologyCellIn vitroBiologyEnzymeRotaxanesScienceQRNiemann-Pick Disease, Type C2-Hydroxypropyl-beta-cyclodextrinStructure-Activity RelationshipNiemann-Pick C1 ProteinMedicineHumansLysosomesResearch Article

Sustainable Development Goals

SDG 3: 3. Good health

Structure-function relationships of cholesterol mobilization from the endo-lysosome compartment of NPC1-deficient human cells by β-CD polyrotaxanes

FAIR Checklist

Authors (8)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)