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Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells

PLoS ONE(2022)10.1371/journal.pone.0276579Source: DataRank Database

Inhibiting glutamine utilization creates a synthetic lethality for suppression of ATP citrate lyase in KRas-driven cancer cells is a research paper published in PLoS ONE (2022). On theSindex it has a DataRank of 0. It has been cited 11 times.

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Open Access11 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 0.84)OA: goldTopics (73)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Deepak Menon ORCID,Talia Levy,María A. Frías ORCID,David A. Foster ORCID,Ahmet Hatipoğlu ORCID

Live enrichment

PubMed:36269753 PMC:PMC9586366 OpenAlex:https://openalex.org/W4307003099

Center for Scientific Review

Grant: R01-CA179542

NCI NIH HHS

Grant: R01 CA179542

National Institutes of Health

Grant: 3R01CA179542-04S1

Dysregulated Metabolic Cell Cycle Checkpoints in Human Cancer

FWCI

0.84

Citation Percentile

0.7%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0276579&type=printable

publisherhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0276579&type=printable

publisherhttps://dx.plos.org/10.1371/journal.pone.0276579

journalhttps://doi.org/10.1371/journal.pone.0276579

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36269753

Fields of Study

Cancer, Hypoxia, and MetabolismATP Synthase and ATPases ResearchCancer Research and Treatments0301 basic medicine03 medical and health sciencesHumansAdenosine Diphosphate RiboseAminooxyacetic AcidATP Citrate (pro-S)-LyaseGlutamatesGlutamineKetoglutaric AcidsMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2NeoplasmsOleic AcidsOxaloacetatesPhosphatidic AcidsProto-Oncogene Proteins c-aktTransaminasesProto-Oncogene Proteins p21(ras)

MeSH Terms

Mechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2Adenosine Diphosphate RiboseAminooxyacetic AcidTransaminasesATP Citrate (pro-S)-LyaseGlutamatesGlutamineHumansKetoglutaric AcidsNeoplasmsOleic AcidsOxaloacetatesPhosphatidic AcidsProto-Oncogene Proteins p21(ras)Proto-Oncogene Proteins c-akt

Keywords

ATP citrate lyaseSynthetic lethalityGlutamineCancer cellChemistryBiochemistryAdenosine triphosphateCancerCell biologyBiologyEnzymeCitrate synthaseGeneticsDNA repairAmino acidGeneAdenosine Diphosphate RiboseOxaloacetatesScienceQRAminooxyacetic AcidPhosphatidic AcidsOleic AcidsMechanistic Target of Rapamycin Complex 2Mechanistic Target of Rapamycin Complex 1Proto-Oncogene Proteins p21(ras)GlutamatesNeoplasmsATP Citrate (pro-S)-LyaseMedicineHumansKetoglutaric AcidsProto-Oncogene Proteins c-aktTransaminasesResearch Article

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being