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Intranasal respiratory syncytial virus vaccine attenuated by codon-pair deoptimization of seven open reading frames is genetically stable and elicits mucosal and systemic immunity and protection against challenge virus replication in hamsters

PLoS Pathogens(2024)10.1371/journal.ppat.1012198Source: DataRank Database

Intranasal respiratory syncytial virus vaccine attenuated by codon-pair deoptimization of seven open reading frames is genetically stable and elicits mucosal and systemic immunity and protection against challenge virus replication in hamsters is a research paper published in PLoS Pathogens (2024). On theSindex it has a DataRank of 0. It has been cited 12 times.

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Open Access12 citations

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Enrichment:Funding (2 grants)Impact (FWCI 3.78)OA: goldTopics (31)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Jessica W. Chen ORCID,Jaclyn A. Kaiser,Hong-Su Park ORCID,Xueqiao Liu ORCID,Lijuan Yang ORCID

Live enrichment

PubMed:38739647 PMC:PMC11115275 OpenAlex:https://openalex.org/W4396853108

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Grant: ZIA AI000372-40

Intramural NIH HHS

Grant: ZIA AI000372

FWCI

3.78

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012198&type=printable

publisherhttps://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012198&type=printable

publisherhttps://dx.plos.org/10.1371/journal.ppat.1012198

journalhttps://doi.org/10.1371/journal.ppat.1012198

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38739647

Fields of Study

Respiratory viral infections researchViral gastroenteritis research and epidemiologyVirus-based gene therapy research

MeSH Terms

Administration, IntranasalAnimalsAntibodies, ViralCodonCricetinaeHumansMesocricetusRespiratory Syncytial VirusesVaccines, AttenuatedVirus ReplicationOpen Reading FramesRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsImmunity, MucosalRespiratory Syncytial Virus Vaccines

Keywords

VirologyBiologyORFSVirusViral replicationAttenuated vaccineOpen reading frameReverse transcriptaseStop codonGeneGeneticsRNAPeptide sequence

Sustainable Development Goals

SDG 0: Good health and well-being

Intranasal respiratory syncytial virus vaccine attenuated by codon-pair deoptimization of seven open reading frames is genetically stable and elicits mucosal and systemic immunity and protection against challenge virus replication in hamsters

FAIR Checklist

Authors (9)

Funding (2 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)