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The elevated expression of ORF75, a KSHV lytic gene, in Kaposi sarcoma lesions is driven by a GC-rich DNA cis element in its promoter region

PLoS Pathogens(2025)10.1371/journal.ppat.1012984Source: DataRank Database

The elevated expression of ORF75, a KSHV lytic gene, in Kaposi sarcoma lesions is driven by a GC-rich DNA cis element in its promoter region is a research paper published in PLoS Pathogens (2025). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)Impact (FWCI 0.00)OA: goldTopics (58)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

David A. Davis ORCID,Andrew Warner ORCID,Baktiar Karim ORCID,Ramya Ramaswami ORCID,Robert Yarchoan ORCID

Live enrichment

PubMed:40096169 PMC:PMC11981178 OpenAlex:https://openalex.org/W4408520691

US National Cancer Institute

Grant: ZIA BC010885

National Institutes of Health

Grant: 1ZIABC010885-11

Study of Tumor Pathogenesis and Development of Therapies for AIDS Malignancies

FWCI

0.00

Citation Percentile

0.1%

goldLicense: cc-by

journalhttps://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012984&type=printable

publisherhttps://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1012984&type=printable

publisherhttps://dx.plos.org/10.1371/journal.ppat.1012984

journalhttps://doi.org/10.1371/journal.ppat.1012984

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40096169

Fields of Study

Viral-associated cancers and disordersCytomegalovirus and herpesvirus researchParvovirus B19 Infection Studies0301 basic medicine03 medical and health sciencesHerpesvirus 8, HumanHumansSarcoma, KaposiPromoter Regions, GeneticGene Expression Regulation, ViralViral ProteinsSp1 Transcription FactorOpen Reading FramesAntigens, ViralDNA, ViralVirus ReplicationNuclear Proteins

MeSH Terms

Antigens, ViralDNA, ViralHumansNuclear ProteinsPromoter Regions, GeneticSarcoma, KaposiViral ProteinsVirus ReplicationGene Expression Regulation, ViralSp1 Transcription FactorOpen Reading FramesHerpesvirus 8, Human

Keywords

Lytic cycleKaposi's sarcoma-associated herpesvirusBiologyPrimary effusion lymphomaMolecular biologyPromoterGene expressionGeneVirologyVirusGeneticsHerpesviridaeGene Expression Regulation, ViralQH301-705.5Sp1 Transcription FactorNuclear ProteinsRC581-607Virus ReplicationViral ProteinsOpen Reading FramesHerpesvirus 8, HumanDNA, ViralHumansImmunologic diseases. AllergyBiology (General)Promoter Regions, GeneticSarcoma, KaposiAntigens, ViralResearch Article