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Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

The EMBO Journal(2021)10.15252/embj.2020106048Source: DataRank Database

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner is a research paper published in The EMBO Journal (2021). On theSindex it has a DataRank of 0. It has been cited 212 times.

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Enrichment:Funding (35 grants)Impact (FWCI 17.82)OA: hybridTopics (56)Linked Datasets (14)DataCite Reuse (14)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

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Accessible (1/2)

Open Access

Interoperable (2/2)

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Authors (37)

Jack Leslie ORCID,Marie‐Hélène Ruchaud‐Sparagano,Stella Victorelli ORCID,Petra Hirsova ORCID,Mikołaj Ogrodnik ORCID

Live enrichment

PubMed:33764576 PMC:PMC8090854 OpenAlex:https://openalex.org/W3136466881

UKRI | Biotechnology and Biological Sciences Research Council

Grant: BB/K017314/1

Regulation of DNA damage signaling by autophagy in senescence

UKRI | Biotechnology and Biological Sciences Research Council

Grant: BB/L502066/1

The impact of melanocyte senescence on skin ageing

HHS | National Institutes of Health

Grant: P01 AG062413

HHS | National Institutes of Health

Grant: R01 AG050582

Cancer Research UK

Grant: C18342/A23390

UKRI | Medical Research Council

Grant: MR/K0019494/1

UKRI | Medical Research Council

Grant: MR/R023026/1

MICA: Molecular drivers of fibrosis at the hepatic epithelial-mesenchymal barrier

HHS | NIH | National Institute on Aging

Grant: R01 AG 68048

HHS | NIH | National Institute on Aging

Grant: R01 AG068182‐01

HHS | NIH | National Institute on Aging

Grant: R37 AG013925

HHS | NIH | National Center for Advancing Translational Sciences

Grant: UL1 TR0002377

Cancer Research UK

Grant: S_4276

Biotechnology and Biological Sciences Research Council

Grant: BB/S006710/1

NIDDK NIH HHS

Grant: P30 DK084567

NIA NIH HHS

Grant: R01 AG068048

NIA NIH HHS

Grant: R01 AG068182

Cancer Research UK

Grant: 26813

Medical Research Council

Grant: MR/K001949/1

Medical Research Council

Grant: G0900535

Academy of Medical Sciences

Grant: SBF005\1130

NIA NIH HHS

Grant: T32 AG049672

NCATS NIH HHS

Grant: UL1 TR002377

Cancer Research UK

Grant: 23390

National Centre for the Replacement, Refinement and Reduction of Animals in Research

Grant: NC/K000748/1

NCI NIH HHS

Grant: UG3 CA268103

National Institutes of Health

Grant: 3P01AG062413-02S1

Targeting Cellular Senescence to Extend Healthspan

National Institutes of Health

Grant: 5R01AG068048-03

The role of sub-lethal mitochondrial apoptotic stress in cellular senescence

National Institutes of Health

Grant: 3UL1TR002377-04S5

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Regan Theiler)

National Institutes of Health

Grant: 3R37AG013925-16S1

Effect of Aging on Preadipocyte Differentiation

European Commission

Grant: 683000

Cellular and molecular mechanisms of metabolic immune activation triggering non-alcoholic steatohepatitis (NASH) and HCC

National Institutes of Health

Grant: 5P30DK084567-05

CLINICAL CORE

National Institutes of Health

Grant: 5R01AG050582-02

The Role of Somatic Transposition in Age-associated Genomic Instability

National Institutes of Health

Grant: 1R01AG068182-01

Does obesity exacerbate age-related cognitive decline via senescence?

American Association for the Study of Liver Diseases

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

FWCI

17.82

Citation Percentile

1.0%

Citation Trend

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2020106048

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2020106048

publisherhttps://link.springer.com/content/pdf/10.15252/embj.2020106048.pdf

publisherhttps://onlinelibrary.wiley.com/doi/full-xml/10.15252/embj.2020106048

publisherhttps://link.springer.com/article/10.15252/embj.2020106048/fulltext.html

Fields of Study

Telomeres, Telomerase, and SenescenceNeutrophil, Myeloperoxidase and Oxidative MechanismsSkin Protection and Aging0301 basic medicine03 medical and health sciences

MeSH Terms

AnimalsCarbon TetrachlorideCell LineDisease Models, AnimalFemaleFibroblastsHumansMaleNeutrophilsCellular SenescenceReactive Oxygen SpeciesOxidative StressCoculture TechniquesParacrine CommunicationMiceAcute Lung InjuryTelomere Shortening

Keywords

BiologyTelomereParacrine signallingSenescenceCellular senescenceCell biologyTelomeraseDNA damageCellular AgingGeneticsDNAPhenotypeGeneAgingNeutrophilsTelomeresMale570Acute Lung Injury610Cell LineMiceParacrine CommunicationAnimalsHumansCarbon TetrachlorideTelomere ShorteningArticlesFibroblastsCoculture TechniquesDisease Models, AnimalOxidative StressFemaleReactive Oxygen Species

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis

10.6084/m9.figshare.19084074.v1figshare

Additional file 1 of Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis

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Additional file 2 of Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis

10.6084/m9.figshare.19084077.v1figshare

Additional file 2 of Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis

10.6084/m9.figshare.19084077figshare

Additional file 2 of Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

10.6084/m9.figshare.20153143.v1figshare

Additional file 2 of Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

10.6084/m9.figshare.20153143figshare

Additional file 1 of Clinical assessment and molecular mechanism of the upregulation of Toll-like receptor 2 (TLR2) in myocardial infarction

10.6084/m9.figshare.20327380figshare

Additional file 1 of Clinical assessment and molecular mechanism of the upregulation of Toll-like receptor 2 (TLR2) in myocardial infarction

10.6084/m9.figshare.20327380.v1figshare

Additional file 1 of Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

10.6084/m9.figshare.20153140figshare

Additional file 4 of Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

10.6084/m9.figshare.20153149figshare

Additional file 3 of Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

10.6084/m9.figshare.20153146.v1figshare

Additional file 4 of Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

10.6084/m9.figshare.20153149.v1figshare

Additional file 1 of Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

10.6084/m9.figshare.20153140.v1figshare

Additional file 3 of Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

10.6084/m9.figshare.20153146figshare

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Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

FAIR Checklist

Authors (37)

Funding (35 grants)

Impact

Open Access

Topics

Linked Datasets (14)

Annotations (Europe PMC)

Related Papers (10)