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Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole

EMBO Reports(2021)10.15252/embr.202153233Source: DataRank Database

Structural mechanism of TRPV3 channel inhibition by the plant-derived coumarin osthole is a research paper published in EMBO Reports (2021). On theSindex it has a DataRank of 1.4. It has been cited 59 times, with 45 citing works in its 1-hop citation network.

N/A

1.4DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access59 citations · 45 citing works in its network

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Linked data & code

pdb

Data availability

Repositories this paper deposited data in (declared in PubMed).

PDB7RAS 7RAU

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (15 grants)Impact (FWCI 6.74)OA: bronzeTopics (36)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 45%Citation Network 55%

Base Score Contribution

0.614

From this paper's citation signal

Citation Network Contribution

0.762

From 32 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 45 citers.

Dyclonine inhibition of TRPV3: From functional discovery to structural insight
Cell Calcium20223 citations11 referencesContributes 0.126
The coumarin osthole is a non-electrophilic agonist of TRPA1
Neuroscience Letters20229 citations27 referencesContributes 0.085
Structural basis of TRPV3 inhibition by an antagonist
Nature Chemical Biology202242 citations62 referencesContributes 0.061
Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels
British Journal of Pharmacology202260 citations77 referencesContributes 0.053
Selective inhibition of overactive warmth-sensitive Ca2+-permeable TRPV3 channels by antispasmodic agent flopropione for alleviation of skin inflammation
Journal of Biological Chemistry20239 citations48 referencesContributes 0.048

Authors (4)

Kirill D. Nadezhdin ORCID,Eleonora Zakharian ORCID,Alexander I. Sobolevsky ORCID,Arthur Neuberger ORCID

Live enrichment

PubMed:34472684 PMC:PMC8567229 OpenAlex:https://openalex.org/W3198788548

HHS | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute

Grant: CA206573

HHS | NIH | National Institute of Neurological Disorders and Stroke

Grant: NS083660

HHS | NIH | National Institute of Neurological Disorders and Stroke

Grant: NS107253

NSF | BIO | Division of Molecular and Cellular Biosciences

Grant: 1818086

NSF/MCB-BSF: Collaborative Research: Towards development of the structural determinants of the Glutamate receptor gating regulation by auxiliary membrane anchored proteins

NSF | BIO | Division of Molecular and Cellular Biosciences

Grant: 1922428

Rapid testosterone signaling receptor TRPM8 regulates sexual reward and satiety

Deutsche Forschungsgemeinschaft

Grant: 464295817

NINDS NIH HHS

Grant: R01 NS107253

NIAMS NIH HHS

Grant: R01 AR078814

NINDS NIH HHS

Grant: R01 NS083660

NINDS NIH HHS

Grant: R37 NS083660

NCI NIH HHS

Grant: R01 CA206573

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5R01CA206573-05

Structure and function of Transient Receptor Potential channels

National Institutes of Health

Grant: 5R01NS083660-03

Structure and Finction of AMPA subtype ionotropic glutamate receptors

National Institutes of Health

Grant: 5R01NS107253-02

Single-particle cryo-EM characterization of AMPA receptor functional states

FWCI

6.74

Citation Percentile

1.0%

Influential Citations

Citation Trend

2021

2022

2023

2024

2025

2026

bronzeLicense: Springer TDM

journalhttps://link.springer.com/content/pdf/10.15252/embr.202153233.pdf

CLOSEDhttps://doi.org/10.15252/embr.202153233

publisherhttps://link.springer.com/content/pdf/10.15252/embr.202153233.pdf

publisherhttps://onlinelibrary.wiley.com/doi/full-xml/10.15252/embr.202153233

publisherhttps://link.springer.com/article/10.15252/embr.202153233/fulltext.html

Fields of Study

Essential Oils and Antimicrobial ActivityPlant chemical constituents analysisIon Channels and ReceptorsMedicineChemistryBiology0301 basic medicine03 medical and health sciencesCoumarinsHumansKeratinocytesSkinTRPV Cation Channels

MeSH Terms

CoumarinsHumansSkinKeratinocytesTRPV Cation Channels

Keywords

CoumarinChemistryIntracellularPharmacologyAgonistBiochemistryBiologyReceptorOstholeTrp ChannelsCompetitive InhibitorCryo-emSingle-channel RecordingsKeratinocytesCoumarinsHumansTRPV Cation ChannelsSkin

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being