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NPM1 ablation induces HSC aging and inflammation to develop myelodysplastic syndrome exacerbated by p53 loss

EMBO Reports(2022)10.15252/embr.202154262Source: DataRank Database

NPM1 ablation induces HSC aging and inflammation to develop myelodysplastic syndrome exacerbated by p53 loss is a research paper published in EMBO Reports (2022). On theSindex it has a DataRank of 0. It has been cited 35 times.

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Scored on demand from live citation data

Open Access35 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (19 grants)Impact (FWCI 4.73)OA: bronzeTopics (52)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Kyoko Ito ORCID,Chie Yanase,Amit Verma ORCID,Julie Teruya‐Feldstein ORCID,Keisuke Ito ORCID

Live enrichment

PubMed:35229971 PMC:PMC9066051 OpenAlex:https://openalex.org/W4214581683

HHS | NIH | National Heart, Lung, and Blood Institute

Grant: R01HL148852

HHS | NIH | National Heart, Lung, and Blood Institute

Grant: R01HL139487

HHS | NIH | National Heart, Lung, and Blood Institute

Grant: R01HL150832

HHS | NIH | National Heart, Lung, and Blood Institute

Grant: R01HL069438

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Grant: R01DK098263

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Grant: R01DK115577

HHS | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute

Grant: P30CA013330

New York State Department of Health

Grant: C029154

New York State Department of Health

Grant: C34874GG

Leukemia & Lymphoma Society

Grant: 1360‐19

NCI NIH HHS

Grant: P30 CA008748

National Institutes of Health

Grant: 5R01HL148852-03

Dissecting the canonical and non-canonical functions of Tet2 in hematopoietic stem cells and hematologic disorders

National Institutes of Health

Grant: 1R01DK115577-01

Single cell approach to uncovering factors regulating HSC division symmetry in vivo

National Institutes of Health

Grant: 5R01HL150832-02

STAT3 inhibition as a therapeutic strategy against MDS stem cells

National Institutes of Health

Grant: 5R01DK098263-13

The Roles of Lipid Metabolism in the Maintenance of Hematopoietic Stem Cells

National Institutes of Health

Grant: 1ZIADK013039-04

Molecular modeling of soluble proteins

National Institutes of Health

Grant: 3P30CA013330-39S3

Core Support for Cancer Center

National Institutes of Health

Grant: 5R01HL069438-20

In vivo mechanisms mediating sickle cell vaso-occlusion

National Institutes of Health

Grant: 1R01HL139487-01A1

Therapeutic targeting of MDS stem cells

FWCI

4.73

Citation Percentile

1.0%

Citation Trend

2022

2023

2024

2025

2026

bronzeLicense: Springer TDM

journalhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embr.202154262

publisherhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embr.202154262

publisherhttps://link.springer.com/content/pdf/10.15252/embr.202154262.pdf

publisherhttps://onlinelibrary.wiley.com/doi/full-xml/10.15252/embr.202154262

publisherhttps://link.springer.com/article/10.15252/embr.202154262/fulltext.html

Fields of Study

Acute Myeloid Leukemia ResearchOccupational and environmental lung diseasesTelomeres, Telomerase, and Senescence0301 basic medicine03 medical and health sciencesAgingAnimalsHematopoietic Stem CellsHumansInflammationLeukemia, Myeloid, AcuteMiceMutationMyelodysplastic SyndromesNuclear ProteinsNucleophosminTumor Suppressor Protein p53

MeSH Terms

NucleophosminAgingAnimalsHematopoietic Stem CellsHumansInflammationMutationMyelodysplastic SyndromesNuclear ProteinsLeukemia, Myeloid, AcuteTumor Suppressor Protein p53Mice

Keywords

InflammationMyelodysplastic syndromesGerontologyCancer researchMedicineBiologyInternal medicineBone marrowMDSNpm1Tp53Nlrp3Hsc AgingAgingNuclear ProteinsHematopoietic Stem CellsLeukemia, Myeloid, AcuteMiceMutationAnimalsHumansTumor Suppressor Protein p53Nucleophosmin

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Quality Education