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Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

UNC Libraries(2024)10.17615/8s5m-e911Source: DataRank Database

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site is a research paper published in UNC Libraries (2024). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (14 grants)Impact (FWCI 0.00)OA: greenTopics (39)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (24)

Roth B.L,András Váradi ORCID,Simons C.A.,C. H. T,Abdullah Allaoa

Live enrichment

PubMed:26657633 OpenAlex:https://openalex.org/W4400026215

National Institutes of Health

Grant: 7R01DA007242-28

Pharmacology of opioid actions in vivo

National Institutes of Health

Grant: 7R01DA042888-05

Alternative pre-mRNA splicing of mu opioid receptor gene and mu opioid actions

National Institutes of Health

Grant: 5R01MH054137-25

Structure and Function of Dopamine Receptors

National Institutes of Health

Grant: 5P01DA035764-05

Structure-Function of Opioid Receptors

National Institutes of Health

Grant: 1R21DA046714-01

Mapping mu agonist-induced receptor-protein interactions for OPRM1 7TM variants

National Institutes of Health

Grant: 2T32MH018870-06

SCHIZOPHRENIA RESEARCH TRAINING

National Institutes of Health

Grant: 5R21AA026949-02

Opioidergic alkaloids from Mitragynia Speciosa (kratom) as novel treatment for alcohol use disorder

National Institutes of Health

Grant: 5R01DA006241-27

Synthesis and pharmacology of novel opiates and their modulatory systems

National Institutes of Health

Grant: 5R33DA038858-04

Rational discovery of new DOR chemotypes to prevent addiction and overdose

National Institutes of Health

Grant: 2P30CA008748-43

MOUSE GENETICS

National Institutes of Health

Grant: 1R01MH112205-01

Molecular Details of Psychoactive Drug Actions

National Institutes of Health

Grant: 4R33DA045884-03

Pharmacological Probes based on mitragynine pseudoindoxyl

National Institutes of Health

Grant: 5R37DA045657-04

Mechanistic insights into LSD actions at 5-HT2A serotonin receptors

National Institutes of Health

Grant: 5R01DA046487-03

Chemistry and Biology of Mitragynine Alkaloids

FWCI

0.00

Citation Percentile

0.1%

greenLicense: CC BY

repositoryhttps://doi.org/10.17615/8s5m-e911

https://doi.org/10.7554/elife.56519

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909954

https://dx.doi.org/10.17615/8s5m-e911

https://pubmed.ncbi.nlm.nih.gov/33555255

Fields of Study

Receptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyPharmacological Receptor Mechanisms and Effects0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

OpioidOpioid receptorFunctional selectivityPharmacologyReceptorChemistryBiologyG protein-coupled receptorBiochemistryMaleQH301-705.5ScienceAmino Acid MotifsReceptors, Opioid, muLigandsMiceStructure-Activity RelationshipBiochemistry and Chemical BiologyAnimalsBiology (General)safer opioidsAnalgesicsBinding SitesReceptors, Opioid, kappaQRMice, Inbred C57BLMolecular Docking SimulationMorphinansGPCR biasstructure-based drug designMedicineboat/chair

Sustainable Development Goals

SDG 0: Zero hunger