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The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer

Research Square(2020)10.21203/rs.2.15818/v2Source: DataRank Database

The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer is a research paper published in Research Square (2020). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)OA: greenTopics (47)IDs (PubMed, OpenAlex)SDGs (2)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Laura Graham ORCID,Timothy Smith,Carmen Camarena ORCID,Matthew Zellner,Jamie-Jean S Gilmer

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W4256102201

National Institutes of Health

Grant: 3P30CA016059-39S5

VCU Massey Cancer Center Support Grant

National Institutes of Health

Grant: 4P30CA016059-35

Massey Cancer Center Support Grant

greenLicense: cc-by

repositoryhttps://www.researchsquare.com/article/rs-6478/v2.pdf

publisherhttps://www.researchsquare.com/article/rs-6478/v2

publisherhttps://www.researchsquare.com/article/rs-6478/v2.html

repositoryhttps://doi.org/10.21203/rs.2.15818/v2

Fields of Study

Epigenetics and DNA MethylationImmune cells in cancerImmune Cell Function and Interaction03 medical and health sciences0302 clinical medicine

Keywords

MyelopoiesisAdoptive cell transferCancer researchBreast cancerDNA methyltransferaseImmunotherapyAdoptive immunotherapyBiologyCancer immunotherapyImmunologyCancerT cellMethyltransferaseDNACell biologyImmune systemGeneticsProgenitor cellStem cellT lymphocytesAntineoplastic AgentsBreast NeoplasmsDNA methyltransferase inhibitorLymphocyte ActivationImmunotherapy, AdoptiveMiceCell Line, TumorAnimalsHumansDNA Modification MethylasesCell ProliferationMice, Inbred BALB CMyeloid-Derived Suppressor CellsRC581-607Combined Modality TherapyMice, Inbred C57BLMyeloid derived suppressor cellsAzacitidineFemaleImmunologic diseases. AllergyResearch ArticleT-Lymphocytes, Cytotoxic

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being