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TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of Caspase-8/NLRP3 after middle cerebral artery occlusion in rats

Research Square(2020)10.21203/rs.3.rs-115992/v1Source: DataRank Database

TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of Caspase-8/NLRP3 after middle cerebral artery occlusion in rats is a research paper published in Research Square (2020). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Enrichment:Funding (2 grants)OA: greenTopics (28)IDs (PubMed)SDGs (1)

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Authors (8)

Nathanael Matei ORCID,W. McBride Devin,Yang Xu ORCID,Zhenhua Zhou ORCID,Jiping Tang ORCID

Live enrichment

PubMed:33531049

National Institutes of Health

Grant: 5R01NS081740-05

Neurovascular Protection for Early Brain Injury after SAH

National Institutes of Health

Grant: 1P01NS082184-01A1

Neurological and Neurobehavioral Function Evaluation Core

greenLicense: cc-by

repositoryhttps://www.researchsquare.com/article/rs-115992/v1.pdf?c=1631876927000

publisherhttps://www.researchsquare.com/article/rs-115992/v1

publisherhttps://www.researchsquare.com/article/rs-115992/v1.html

https://doi.org/10.21203/rs.3.rs-115992/v1

https://jneuroinflammation.biomedcentral.com/track/pdf/10.1186/s12974-021-02087-1

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

MaleUbiquitin-Protein Ligases610Receptors, G-Protein-CoupledRats, Sprague-DawleyNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsRNA, Small InterferingMiddle cerebral artery occlusionRC346-429Administration, IntranasalInjections, IntraventricularInflammationCaspase 8ResearchTGR5BrainCholic AcidsInfarction, Middle Cerebral ArteryNeuroprotection620RatsNeurology. Diseases of the nervous systemInflammation MediatorsEarly brain injury

Sustainable Development Goals

SDG 3: 3. Good health