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Viral genome sequence datasets display pervasive evidence of strand-specific substitution biases that are best described using non-reversible nucleotide substitution models

Research Square(2025)10.21203/rs.3.rs-2407778/v2Source: DataRank Database

Viral genome sequence datasets display pervasive evidence of strand-specific substitution biases that are best described using non-reversible nucleotide substitution models is a research paper published in Research Square (2025). On theSindex it has a DataRank of 0.

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Enrichment:Funding (9 grants)OA: greenTopics (25)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (9)

Penelope Hartnady,Wimbai Caroline Mandikumba,Kayleigh D. Rutherford,Christopher Brian Currin ORCID,Florence Phelanyane ORCID

Live enrichment

PubMed:36597548 OpenAlex:https://openalex.org/W4413127114

National Science Foundation

Grant: 2027196

Rapid: Collaborative Research: Agile and effective responses to emerging pathogen threats through open data and open analytics

Wellcome Trust

Grant: 222574

National COVID Testing Africa AAPs/Centre

National Institutes of Health

Grant: 5R01AI134384-04

Tuning big data analysis infrastructure for HIV research

National Institutes of Health

Grant: 5R01AI140970-02

HIV Evolution Defines Virus-Host/Drug Interactions In Viremic and Aviremic People

National Institutes of Health

Grant: 1R01GM144468-01A1

Reinventing dN/dS and the study of natural selection

NIAID NIH HHS

Grant: R01 AI134384

NIAID NIH HHS

Grant: R01 AI140970

NIGMS NIH HHS

Grant: R01 GM144468

Wellcome Trust

greenLicense: cc-by

repositoryhttps://www.researchsquare.com/article/rs-2407778/latest.pdf

publisherhttps://www.researchsquare.com/article/rs-2407778/v2

publisherhttps://www.researchsquare.com/article/rs-2407778/v2.html

repositoryhttps://doi.org/10.21203/rs.3.rs-2407778/v2

Fields of Study

Plant Virus Research StudiesBacteriophages and microbial interactionsRNA and protein synthesis mechanisms0301 basic medicine03 medical and health sciences

Keywords

Substitution (logic)Sequence (biology)Computational biologyNucleotideGeneticsGenomeBiologyComputer scienceGeneEvolution, MolecularEvolutionary BiologyModels, GeneticMutationGenome, ViralArticlePhylogenyModels of evolutionMutationsNon-reversibilityReversibility

Sustainable Development Goals

SDG 3: 3. Good health