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CERTL reduces C16 ceramide, amyloid-β levels and inflammation in a model of Alzheimer's disease

Research Square(2020)10.21203/rs.3.rs-42740/v2Source: DataRank Database

CERTL reduces C16 ceramide, amyloid-β levels and inflammation in a model of Alzheimer's disease is a research paper published in Research Square (2020). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)OA: greenTopics (44)IDs (PubMed)SDGs (3)

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Authors (23)

Qian Luo ORCID,Jo Stevens ORCID,Caterina Giovagnoni,Daan van Kruining ORCID,Gerard H. Bode

Live enrichment

PubMed:30945415

National Institutes of Health

Grant: 1R56AG064234-01

Regulation of microglial activation state in neurodegeneration

National Institutes of Health

Grant: 5R01NS095215-04

Regulation of cilia by ceramide

National Institutes of Health

Grant: 1R01AG064234-01A1

Regulation of Microglial Activation State by a Lipid Transporter

National Institutes of Health

Grant: 5I01BX003643-04

TBI-induced exosome release accelerates Alzheimer's disease pathology

National Institutes of Health

Grant: 1R01AG049704-01

Sphingolipids and Inflammation in the Development and Progression of Alzheimer's

National Institutes of Health

Grant: 5R01AG034389-07

Function of ceramide in neurodegenerative disease

greenLicense: cc-by

repositoryhttps://www.researchsquare.com/article/rs-42740/v2.pdf?c=1631880636000

publisherhttps://www.researchsquare.com/article/rs-42740/v2

publisherhttps://www.researchsquare.com/article/rs-42740/v2.html

https://doi.org/10.21203/rs.3.rs-42740/v3

https://alzres.biomedcentral.com/track/pdf/10.1186/s13195-021-00780-0

Fields of Study

0302 clinical medicine03 medical and health sciences

Keywords

SphingomyelinMalealzheimer's disease (ad)Adeno-associated virus (AAV)microgliaAlzheimer’s disease (AD)Plaque, Amyloid5xfadneuroinflammationCeramideNEURON LOSSAmyloid beta-Protein PrecursorMicePEPTIDEBRAININ-VIVOTRANSGENIC MICEddc:610SPHINGOLIPID METABOLISMAmyloid-β plaquesRC346ceramide transporter protein (cert)Amyloid-beta plaquesRC321-571PRECURSOR APPEMC OR-01Neurosciences. Biological psychiatry. NeuropsychiatryMice, TransgenicCeramidesANTIGEN-BINDING PROTEINSDG 3 - Good Health and Well-beingAlzheimer DiseaseAnimalsTRAFFICKINGRC346-429Inflammation5XFAD MOUSE MODELAmyloid beta-PeptidesResearchRC521Disease Models, AnimalNeurology. Diseases of the nervous system

Sustainable Development Goals

SDG 2: 2. Zero hungerSDG 3: 3. Good healthSDG 10: 10. No inequality