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Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer Cells

Research Square(2024)10.21203/rs.3.rs-4542467/v1Source: DataRank Database

Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer Cells is a research paper published in Research Square (2024). On theSindex it has a DataRank of 0.

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Enrichment:Funding (5 grants)OA: greenTopics (36)IDs (PubMed, OpenAlex)SDGs (2)

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Authors (17)

Govinda R Hancock ORCID,Emma C. Fink ORCID,Alexandra Zigrossi,Brenna Flowers ORCID,David A. Cooper

Live enrichment

PubMed:38978585 OpenAlex:https://openalex.org/W4400014307

National Institutes of Health

Grant: 1R37CA279341-01

Structural-Transcriptional Relationships that Improve Y537S Estrogen Receptor Antagonism

National Institutes of Health

Grant: 5P30GM133893-04

The Center for Biomolecular Structure at NSLS-II

NIGMS NIH HHS

Grant: P30 GM133893

NIGMS NIH HHS

Grant: R01 GM127712

NCI NIH HHS

Grant: R37 CA279341

greenLicense: cc-by

repositoryhttps://doi.org/10.21203/rs.3.rs-4542467/v1

publisherhttps://www.researchsquare.com/article/rs-4542467/v1

publisherhttps://www.researchsquare.com/article/rs-4542467/v1.html

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38978585

Fields of Study

Estrogen and related hormone effectsAdvanced Breast Cancer TherapiesUbiquitin and proteasome pathways03 medical and health sciences0302 clinical medicine

Keywords

Cancer researchEstrogen receptor alphaEstrogen receptorSelective estrogen receptor modulatorDownregulation and upregulationBreast cancerCancerChemistryBiologyInternal medicineMedicineBiochemistryGeneSelective Estrogen Receptor ModulatorsResearchNeoplasms. Tumors. Oncology. Including cancer and carcinogensDown-RegulationBreast NeoplasmsLigandsXenograft Model Antitumor AssaysArticleGene Expression Regulation, NeoplasticMiceDrug Resistance, NeoplasmCell Line, TumorMutationHumansIntercellular Signaling Peptides and ProteinsAnimalsFemaleRC254-282

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being