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Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatus

Life Science Alliance(2020)10.26508/lsa.202000729Source: DataRank Database

Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatus is a research paper published in Life Science Alliance (2020). On theSindex it has a DataRank of 1.1. It has been cited 29 times, with 22 citing works in its 1-hop citation network.

N/A

1.1DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access29 citations · 22 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

PDB6Y35 6Y36 6Y37 6Y39 4G92 4G91

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (17 grants)Impact (FWCI 0.51)OA: goldTopics (54)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 47%Citation Network 53%

Base Score Contribution

0.510

From this paper's citation signal

Citation Network Contribution

0.571

From 16 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 22 citers.

Differential Functions of Individual Transcription Factor Binding Sites in the Tandem Repeats Found in Clinically Relevant cyp51A Promoters in Aspergillus fumigatus
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hapE and hmg1 Mutations Are Drivers of cyp51A -Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate
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LWT202417 citations73 referencesContributes 0.040
A Whole Genome Sequencing-Based Approach to Track down Genomic Variants in Itraconazole-Resistant Species of Aspergillus from Iran
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Authors (9)

Matthias Misslinger ORCID,Jasmin Mörl,Fabio Gsaller ORCID,Michael Bromley ORCID,Axel A. Brakhage ORCID

Live enrichment

PubMed:32467317 OpenAlex:https://openalex.org/W3029414443

D-A-CH program Deutsche Forschungsgemeinschaft

Grant: BR 1130/14-1

D-A-CH program Deutsche Forschungsgemeinschaft

Grant: GR 1861/8-1

D-A-CH program Deutsche Forschungsgemeinschaft

Grant: HO 2596/1-1

D-A-CH program Austrian Science Foundation

Grant: FWF-I1346

Wellcome trust

Grant: 208396/Z/17/Z

National Institutes of Health

Grant: R01AI143198-01

Deutsche Forschungsgemeinschaft

Grant: SFB 1309, 325871075

European Community’s Seventh Framework Programme

Grant: FP7/2007-2013

European Community’s Seventh Framework Programme

Grant: BioStruct-X 283570

National Institutes of Health

Grant: 5R01AI143198-03

Analysis of transcription factors determining azole resistance of Aspergillus fumigatus

Deutsche Forschungsgemeinschaft

Grant: 325871075/SFB 1309

Chemical Biology of Epigenetic Modifications

European Commission

Grant: 283570

Transnational access and enhancement of integrated Biological Structure determination at synchrotron X-ray radiation facilities

Wellcome Trust

Grant: 208396

The Aspergillus fumigatus gene and non-coding RNA knockout library

Austrian Science Fund (FWF)

Grant: I 1346

Novel molecular mechanisms of iron sensing and homeostasis in filamentous fungi

Deutsche Forschungsgemeinschaft

Grant: unidentified

unidentified

NIAID NIH HHS

Grant: R01 AI143198

Wellcome Trust

FWCI

0.51

Citation Percentile

0.8%

Citation Trend

2019

2020

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://www.life-science-alliance.org/content/lsa/3/7/e202000729.full.pdf

publisherhttps://www.life-science-alliance.org/content/lsa/3/7/e202000729.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.26508/lsa.202000729

journalhttps://doi.org/10.26508/lsa.202000729

repositoryhttps://pubmed.ncbi.nlm.nih.gov/32467317

Fields of Study

Antifungal resistance and susceptibilityFungal and yeast genetics researchPeptidase Inhibition and Analysis0301 basic medicine0303 health sciences03 medical and health sciencesAmino Acid SequenceAntifungal AgentsAspergillus fumigatusAzolesBase SequenceCCAAT-Binding FactorDrug Resistance, FungalFungal ProteinsMolecular ConformationMutationStructure-Activity Relationship

MeSH Terms

Amino Acid SequenceAntifungal AgentsAspergillus fumigatusAzolesBase SequenceFungal ProteinsMolecular ConformationMutationStructure-Activity RelationshipCCAAT-Binding FactorDrug Resistance, Fungal

Keywords

Aspergillus fumigatusDerepressionMutantBiologyProtein subunitAntifungal drugTranscription factorGeneDemethylaseDrug resistanceMicrobiologyAntifungalGeneticsPsychological repressionGene expressionAzolesAntifungal AgentsBase SequenceMolecular ConformationFungal ProteinsStructure-Activity RelationshipCCAAT-Binding FactorDrug Resistance, FungalMutationAmino Acid SequenceResearch Articles

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being