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Gene expression and chromatin conformation of microglia in virally suppressed people with HIV

Life Science Alliance(2024)10.26508/lsa.202402736Source: DataRank Database

Gene expression and chromatin conformation of microglia in virally suppressed people with HIV is a research paper published in Life Science Alliance (2024). On theSindex it has a DataRank of 0.660. It has been cited 25 times, with 19 citing works in its 1-hop citation network.

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0.660DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access25 citations · 19 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE221688

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (19 grants)Impact (FWCI 4.99)OA: goldTopics (70)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 74%Citation Network 26%

Base Score Contribution

0.489

From this paper's citation signal

Citation Network Contribution

0.172

From 10 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 19 citers.

Microglia Exhibit a Unique Intact HIV Reservoir in Human Postmortem Brain Tissue
Viruses202511 citations65 referencesContributes 0.038
Single cell analyses of the HIV reservoir in the CNS and CSF: recent insights and implications
Current Opinion in HIV and AIDS20256 citations52 referencesContributes 0.037
Advancements in single-cell techniques for examining the HIV reservoir: pathways to a cure
mBio20256 citations71 referencesContributes 0.027
Multi-omic Characterization of HIV Effects at Single Cell Level across Human Brain Regions
bioRxiv (Cold Spring Harbor Laboratory)20256 citations94 referencesContributes 0.021
Eliminating the persistent HIV reservoir based on biomarker expression – How do we get there?
Virology20242 citations59 referencesContributes 0.019

Authors (15)

Sara Gianella ORCID,Zhengyu Ouyang,Addison J. Lana ORCID,Xiaoxu Yang ORCID,S O'Brien

Live enrichment

PubMed:39060113 PMC:PMC11282357 OpenAlex:https://openalex.org/W4401018405

NIH

Grant: 1RF1AG061060-01

Defining the cell-specific epigenetic landscape leading to altered gene expression signatures in HIV-Associated Neurocognitive Disorder

NIH

Grant: 1R21MH134401-01

Mechanisms controlling HIV latency and pathogenesis in microglia

NIH

Grant: K99HD111686

San Diego Center for AIDS Research

Grant: P30 AI036214

NIH

Grant: DA055491

California NeuroAIDS Tissue Network

Grant: U24 MH100928

NIAID NIH HHS

Grant: UM1 AI164559

NIAID NIH HHS

Grant: P01 AI169609

NIMH NIH HHS

Grant: R21 MH134401

NCATS NIH HHS

Grant: UL1 TR001442

NIMH NIH HHS

Grant: P30 MH062512

NIDA NIH HHS

Grant: R01 DA055491

NIA NIH HHS

Grant: RF1 AG061060

National Institutes of Health

Grant: 2UL1TR001442-06

UC San Diego Clinical and Translational Research Institute

National Institutes of Health

Grant: 5P30AI036214-11

Center for AIDS Research

National Institutes of Health

Grant: 5R01DA055491-02

Brain Myeloid Cells are Sources of HIV-associated Damage and Viral Dispersal

National Institutes of Health

Grant: 1P01AI169609-01

Leaving, Coming, and Staying HIV Obligate Microenvironments (HOME)

National Institutes of Health

Grant: 7K99HD111686-03

Understanding genomic stability between generations by assessing mutational burdens in single sperms

National Institutes of Health

Grant: 5U24MH100928-10

California NeuroAIDS Tissue Network

FWCI

4.99

Citation Percentile

1.0%

Citation Trend

2024

2025

2026

goldLicense: cc-by

journalhttps://www.life-science-alliance.org/content/lsa/7/10/e202402736.full.pdf

publisherhttps://www.life-science-alliance.org/content/lsa/7/10/e202402736.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.26508/lsa.202402736

journalhttps://doi.org/10.26508/lsa.202402736

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39060113

Fields of Study

Neuroinflammation and Neurodegeneration MechanismsHIV Research and TreatmentImmune cells in cancer0301 basic medicine03 medical and health sciences0303 health sciencesMicrogliaHumansHIV InfectionsChromatinMaleHIV-1Virus LatencyRNA, ViralBrainFemaleAdultMiddle AgedGene ExpressionViral Load

MeSH Terms

AdultBrainChromatinFemaleHumansMaleMiddle AgedRNA, ViralHIV-1HIV InfectionsGene ExpressionMicrogliaVirus LatencyViral Load

Keywords

MicrogliaChromatinHuman immunodeficiency virus (HIV)Gene expressionGeneCell biologyVirologyBiologyGeneticsImmunologyInflammationMaleAdultBiomedical and clinical sciences610HIV Infections6162.1 Biological and endogenous factorsHumansViralNeurosciencesBrainMiddle AgedViral LoadResourcesVirus LatencyBiological sciencesInfectious DiseasesMedical MicrobiologyHIV-1HIV/AIDSSexually Transmitted InfectionsRNARNA, ViralFemaleInfection

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being