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CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation

Frontiers in Immunology(2020)10.3389/fimmu.2020.02180Source: DataRank Database

CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation is a research paper published in Frontiers in Immunology (2020). On theSindex it has a DataRank of 0. It has been cited 34 times.

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Open Access34 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (22 grants)Impact (FWCI 3.36)OA: goldTopics (98)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (14)

Wen-I Yeh ORCID,Joshua R. Longfield,John T. Gallagher ORCID,Caridad M. Infante,Sarah Wellford

Live enrichment

PubMed:33013915 PMC:PMC7500101 OpenAlex:https://openalex.org/W3083467641

National Institutes of Health

Grant: F31 DK117548

National Institutes of Health

Grant: R01 EY027731

National Institutes of Health

Grant: DP3 DK097605

National Institutes of Health

Grant: P01 AI42288

National Institutes of Health

Grant: R01 DK107541

National Institutes of Health

Grant: R01 DK106191

National Institutes of Health

Grant: R01 DK46266

National Institutes of Health

Grant: DK95735

American Diabetes Association

Grant: 1-16-PDF-131

NIDDK NIH HHS

Grant: R01 DK046266

NIDDK NIH HHS

Grant: R01 DK095735

NIAID NIH HHS

Grant: R21 AI144360

NIDDK NIH HHS

Grant: T32 DK108736

NIAID NIH HHS

Grant: P01 AI042288

NIDDK NIH HHS

Grant: R01 DK121747

National Institutes of Health

Grant: 5R01EY027731-02

Cytokines driving T cell dysregulation in lacrimal gland autoimmunity

National Institutes of Health

Grant: 2R01DK046266-11

Diabetogenic Role of H-2g7 Class I Alleles in NOD Mice

National Institutes of Health

Grant: 5F31DK117548-02

Roles of the Insulin-like Growth Factor Axis in Pre-Type 1 Diabetes Immune Regulation

National Institutes of Health

Grant: 5R01DK106191-02

The CD226 and TIGIT Costimulatory Axis in Type 1 Diabetes

National Institutes of Health

Grant: 1DP3DK097605-01

Discovery and Functional Studies of Genes for T1D GWAS Susceptibility Loci

National Institutes of Health

Grant: 1R01DK107541-01A1

Mechanistic and Therapeutic Role of the CD137-CD137L Axis in Type 1 Diabetes

National Institutes of Health

Grant: 5P01AI042288-17

Administrative Core

FWCI

3.36

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

goldLicense: cc-by

journalhttps://www.frontiersin.org/articles/10.3389/fimmu.2020.02180/pdf

GOLDhttps://www.frontiersin.org/articles/10.3389/fimmu.2020.02180/pdf

publisherhttps://www.frontiersin.org/articles/10.3389/fimmu.2020.02180/pdf

publisherhttps://www.frontiersin.org/article/10.3389/fimmu.2020.02180/full

journalhttps://doi.org/10.3389/fimmu.2020.02180

Fields of Study

Diabetes and associated disordersImmune Cell Function and InteractionT-cell and B-cell ImmunologyMedicineBiology0301 basic medicine03 medical and health sciencesAnimalsAntigens, Differentiation, T-LymphocyteCD5 AntigensCD8-Positive T-LymphocytesCell DifferentiationCells, CulturedDiabetes Mellitus, Type 1Disease Models, AnimalGene Expression RegulationGlucose-6-PhosphataseHumansImmunodominant EpitopesImmunologic MemoryLymphocyte ActivationMiceMice, Inbred NODMice, KnockoutPeripheral ToleranceReceptors, Antigen, T-CellThymocytesT Lineage-Specific Activation Antigen 1

MeSH Terms

T Lineage-Specific Activation Antigen 1AnimalsAntigens, Differentiation, T-LymphocyteCell DifferentiationCells, CulturedDiabetes Mellitus, Type 1Disease Models, AnimalGene Expression RegulationGlucose-6-PhosphataseHumansImmunologic MemoryLymphocyte ActivationReceptors, Antigen, T-CellImmunodominant EpitopesMice, Inbred NODMice, KnockoutCD8-Positive T-LymphocytesCD5 AntigensMiceThymocytesPeripheral Tolerance

Keywords

NOD miceInsulitisT cellBiologyCD8Cytotoxic T cellImmunologyThymocyteTIGITAdoptive cell transferCell biologyEndocrinologyInternal medicineAntigenImmune systemAutoimmunityMedicineCD226type 1 diabetesCd8+ T CellsCostimulatory ReceptorsSjögren’S DiseaseAntigens, Differentiation, T-LymphocyteReceptors, Antigen, T-Cell610CD8-Positive T-LymphocytesCD5 AntigensLymphocyte ActivationMiceMice, Inbred NODMedicine and Health SciencesAnimalsHumansCells, CulturedJMGMice, KnockoutThymocytesImmunodominant EpitopesPeripheral ToleranceLife SciencesCell DifferentiationRC581-607Disease Models, AnimalDiabetes Mellitus, Type 1Gene Expression RegulationGlucose-6-PhosphataseSjÃ¶grenâ€™s diseaseImmunologic diseases. AllergyImmunologic Memory

Sustainable Development Goals

SDG 0: Good health and well-being