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Dysregulated TP53 Among PTSD Patients Leads to Downregulation of miRNA let-7a and Promotes an Inflammatory Th17 Phenotype

Frontiers in Immunology(2022)10.3389/fimmu.2021.815840Source: DataRank Database

Dysregulated TP53 Among PTSD Patients Leads to Downregulation of miRNA let-7a and Promotes an Inflammatory Th17 Phenotype is a research paper published in Frontiers in Immunology (2022). On theSindex it has a DataRank of 0. It has been cited 19 times.

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Open Access19 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (15 grants)Impact (FWCI 2.03)OA: goldTopics (83)Linked Datasets (2)DataCite Reuse (2)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (10)

Marpe Bam,Xiaoming Yang ORCID,Osama A. Abdulla ORCID,Juhua Zhou ORCID,J. P. Ginsberg ORCID

Live enrichment

PubMed:35058939 OpenAlex:https://openalex.org/W4206277095

National Institutes of Health

Grant: R01ES019313, R01MH094755, R01AI123947, R01AI129788, P01AT003961, R01AT006888, P20GM103641

National Institutes of Health

Grant: 5R01MH094755-02

Immunopathological basis of PTSD

National Institutes of Health

Grant: 1R01AI129788-01

Epigenetic Mechanisms of T Cell Dysregulation in PTSD

National Institutes of Health

Grant: 7R01AT006888-03

Role of natural indoles in experimental autoimmune encephalomyelitis

National Institutes of Health

Grant: 5R01ES019313-03

Estrogen-T cell Interactions

National Institutes of Health

Grant: 5P20GM103641-07

Dietary Supplements and Inflammation Phase-2

National Institutes of Health

Grant: 5P01AT003961-10

CAM Center for Epigenetic Regulation of Inflammation

National Institutes of Health

Grant: 5R01AI123947-04

AhR ligands in epigenetic dysregulation of T cells

NIAID NIH HHS

Grant: R01 AI129788

NIMH NIH HHS

Grant: R01 MH094755

NIEHS NIH HHS

Grant: R01 ES019313

NIGMS NIH HHS

Grant: P20 GM103641

NCCIH NIH HHS

Grant: P01 AT003961

NCCIH NIH HHS

Grant: R01 AT006888

NIAID NIH HHS

Grant: R01 AI123947

FWCI

2.03

Citation Percentile

0.8%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.815840/pdf

publisherhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.815840/pdf

publisherhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.815840/full

journalhttps://doi.org/10.3389/fimmu.2021.815840

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35058939

Fields of Study

Anesthesia and Neurotoxicity ResearchCancer, Stress, Anesthesia, and Immune ResponseStress Responses and Cortisol0301 basic medicine03 medical and health sciencesAdultBiomarkersDNA MethylationFemaleGene Expression RegulationHumansImmunophenotypingLeukocytes, MononuclearLymphocyte ActivationMaleMicroRNAsMiddle AgedPhenotypePromoter Regions, GeneticRNA InterferenceSeverity of Illness IndexStress Disorders, Post-TraumaticTh17 CellsTumor Suppressor Protein p53

MeSH Terms

AdultFemaleGene Expression RegulationHumansLeukocytes, MononuclearLymphocyte ActivationMaleMiddle AgedPhenotypePromoter Regions, GeneticSeverity of Illness IndexStress Disorders, Post-TraumaticBiomarkersImmunophenotypingTumor Suppressor Protein p53DNA MethylationRNA InterferenceMicroRNAsTh17 Cells

Keywords

EpigeneticsmicroRNAPeripheral blood mononuclear cellDNA methylationProinflammatory cytokinePhenotypeDownregulation and upregulationInflammationImmunologyMethylationPopulationMedicineGene expressionBiologyCancer researchGeneIn vitroGeneticsAdultMaleT helper 17 cellsLymphocyte ActivationSeverity of Illness IndexImmunophenotypingStress Disorders, Post-TraumaticHumansPromoter Regions, GeneticRC581-607Middle AgedMicroRNAsGene Expression RegulationLeukocytes, Mononuclearpost-traumatic stress disorderTh17 CellsFemaleRNA InterferenceImmunologic diseases. AllergyTumor Suppressor Protein p53Biomarkerstumor protein 53

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of Study of the curative effect of Zhang’s Xibi formula and its underlying mechanism involving inhibition of inflammatory responses and delay of knee osteoarthritis

10.6084/m9.figshare.24819462.v1figshare

Additional file 1 of Study of the curative effect of Zhang’s Xibi formula and its underlying mechanism involving inhibition of inflammatory responses and delay of knee osteoarthritis

10.6084/m9.figshare.24819462figshare