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Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models

Frontiers in Immunology(2022)10.3389/fimmu.2022.880108Source: DataRank Database

Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models is a research paper published in Frontiers in Immunology (2022). On theSindex it has a DataRank of 0. It has been cited 20 times.

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Enrichment:Funding (6 grants)OA: goldTopics (31)IDs (PubMed, PMC)

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Authors (8)

Lauren B. Ostermann ORCID,Muharrem Müftüoğlu ORCID,Abishek Vaidya ORCID,Challice L. Bonifant ORCID,Mireya Paulina Velasquez ORCID

Live enrichment

PubMed:35615350 PMC:PMC9124830

NCI NIH HHS

Grant: P30 CA016672

National Institutes of Health

Grant: 3P30CA016672-41S4

Cancer Center Support (CORE) Grant

American Lebanese Syrian Associated Charities

Leukemia and Lymphoma Society

National Institutes of Health

Cancer Prevention and Research Institute of Texas

goldLicense: cc-by

publisherhttps://www.frontiersin.org/articles/10.3389/fimmu.2022.880108/pdf

publisherhttps://www.frontiersin.org/articles/10.3389/fimmu.2022.880108/full

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9124830

Europe_PMChttps://europepmc.org/articles/PMC9124830

Europe_PMChttps://europepmc.org/articles/PMC9124830?pdf=render

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

T-LymphocytesCell Line, TumorAnimalsAnimals, Genetically ModifiedHumansInterleukin-15Immunotherapy, AdoptiveCell DifferentiationInterleukin-3 Receptor alpha SubunitLeukemia, Myeloid, Acute

Keywords

T cellsImmunotherapyAMlCD123BiteIl15Interleukin-15T-LymphocytesImmunologyInterleukin-3 Receptor alpha SubunitCell DifferentiationRC581-607Immunotherapy, AdoptiveAnimals, Genetically ModifiedLeukemia, Myeloid, AcuteCell Line, TumorAnimalsHumansImmunologic diseases. Allergy