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Preclinical Evaluation of a Novel Dual Targeting PI3Kδ/BRD4 Inhibitor, SF2535, in B-Cell Acute Lymphoblastic Leukemia

Frontiers in Oncology(2021)10.3389/fonc.2021.766888Source: DataRank Database

Preclinical Evaluation of a Novel Dual Targeting PI3Kδ/BRD4 Inhibitor, SF2535, in B-Cell Acute Lymphoblastic Leukemia is a research paper published in Frontiers in Oncology (2021). On theSindex it has a DataRank of 0. It has been cited 2 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access2 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)Impact (FWCI 0.07)OA: goldTopics (30)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (19)

Hye Na Kim ORCID,Heather Ogana ORCID,Zesheng Wan,Samantha Hurwitz ORCID,Cydney Nichols ORCID

Live enrichment

PubMed:34926269 PMC:PMC8671162 OpenAlex:https://openalex.org/W3217301782

National Institutes of Health

Grant: R01 CA172896 , CA215656

NCI NIH HHS

Grant: R25 CA225513

NCI NIH HHS

Grant: R01 CA172896

National Institutes of Health

Grant: 5R01CA172896-03

Investigating the mechanism of ITGA4/6-mediated chemoprotection of ALL cells

FWCI

0.07

Citation Percentile

0.4%

Citation Trend

2022

2025

goldLicense: cc-by

journalhttps://doi.org/10.3389/fonc.2021.766888

GOLDhttps://doi.org/10.3389/fonc.2021.766888

publisherhttps://doi.org/10.3389/fonc.2021.766888

publisherhttps://www.frontiersin.org/articles/10.3389/fonc.2021.766888/full

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34926269

Fields of Study

Protein Degradation and InhibitorsCAR-T cell therapy researchAcute Myeloid Leukemia ResearchMedicine0301 basic medicine03 medical and health sciences

Keywords

PI3K/AKT/mTOR pathwayCancer researchDownregulation and upregulationProtein kinase BApoptosisCell cycleChemistryCell growthBRD4Cell cycle checkpointMolecular biologyBiologyAcetylationBromodomainBiochemistryGenec-mycAcute lymphoblastic leukemiaP-aktPi3kδSf2535OncologyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being