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Human Mutant Dynactin Subunit 1 Causes Profound Motor Neuron Disease Consistent with Possible Mechanisms Involving Axonopathy, Mitochondriopathy, Protein Nitration, and T-Cell-Mediated Cytolysis

Biomolecules(2025)10.3390/biom15121637Source: DataRank Database

Human Mutant Dynactin Subunit 1 Causes Profound Motor Neuron Disease Consistent with Possible Mechanisms Involving Axonopathy, Mitochondriopathy, Protein Nitration, and T-Cell-Mediated Cytolysis is a research paper published in Biomolecules (2025). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)Impact (FWCI 0.00)OA: goldTopics (61)IDs (PubMed, PMC, OpenAlex)

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Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (3)

María Clara Franco ORCID,Lee J. Martin ORCID,Victor S. Xie ORCID

Live enrichment

PubMed:41463293 PMC:PMC12730482 OpenAlex:https://openalex.org/W4416466272

National Institute of Neurological Disorder

Grant: RO1NS107417

National Institute of Neurological Disorder

Grant: RO1NS102479

NIH HHS

Grant: 1R01NS107417-04A1

NINDS NIH HHS

Grant: R01 NS102479

FWCI

0.00

Citation Percentile

0.4%

goldLicense: cc-by

journalhttps://www.mdpi.com/2218-273X/15/12/1637/pdf

publisherhttps://www.mdpi.com/2218-273X/15/12/1637/pdf

journalhttps://doi.org/10.3390/biom15121637

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41463293

repositoryhttps://doaj.org/article/c6e51b6a7c7c4a9a894ac4a181a0d58b

Fields of Study

Amyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchGenetic Neurodegenerative DiseasesMedicineBiologyAnimalsHumansMiceAnterior Horn CellsAxonsDynactin ComplexMice, TransgenicMitochondrial DiseasesMotor Neuron DiseaseMotor NeuronsMutationProtein Processing, Post-TranslationalQuinazolinonesSpinal Cord DiseasesT-LymphocytesTyrosineMitochondrial DynamicsMaleFemale

MeSH Terms

Dynactin ComplexAnimalsAnterior Horn CellsAxonsFemaleHumansMaleMice, TransgenicMitochondriaMotor NeuronsMutationProtein Processing, Post-TranslationalSpinal CordSpinal Cord DiseasesT-LymphocytesTyrosineMotor Neuron DiseaseMitochondrial DiseasesMiceQuinazolinonesMitochondrial Dynamics

Keywords

NeurodegenerationChromatolysisMotor neuronProtein subunitMitochondrionAmyotrophic lateral sclerosisMutantCalpainG alpha subunitMitochondriaFASCell deathT cellCD8ALSHeat-shock Protein-90