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LMNA-Related Dilated Cardiomyopathy: Single-Cell Transcriptomics during Patient-Derived iPSC Differentiation Support Cell Type and Lineage-Specific Dysregulation of Gene Expression and Development for Cardiomyocytes and Epicardium-Derived Cells with Lamin A/C Haploinsufficiency

Cells(2024)10.3390/cells13171479Source: DataRank Database

LMNA-Related Dilated Cardiomyopathy: Single-Cell Transcriptomics during Patient-Derived iPSC Differentiation Support Cell Type and Lineage-Specific Dysregulation of Gene Expression and Development for Cardiomyocytes and Epicardium-Derived Cells with Lamin A/C Haploinsufficiency is a research paper published in Cells (2024). On theSindex it has a DataRank of 0. It has been cited 6 times.

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Enrichment:Funding (7 grants)OA: goldTopics (80)IDs (PubMed, PMC)Annotations (2)

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Authors (8)

Thuy-Anh Bui ORCID,Halida P. Widyastuti ORCID,Mehrsa Mehrabi,Zixuan Cang ORCID,Yutong Sha ORCID

Live enrichment

PubMed:39273049 PMC:PMC11394257

NIH National Heart, Lung, and Blood Institute

Grant: 1R01HL129008

NIH National Heart, Lung, and Blood Institute

Grant: NSF: DMS1763272

NIH National Heart, Lung, and Blood Institute

Grant: 594598

NSF-Simons Center for Multiscale Cell Fate Research grants

Grant: DMS1763272 (NSF), 594598 (Simons Foundation)

UCI Office of Research and School of Medicine Intramural Funding

Grant: BFA-11.06.2020

NHLBI NIH HHS

Grant: R01 HL129008

National Institutes of Health

Grant: 5R01HL129008-04

Cardiac Functional and Structural Implications of Lamin A/C Mutations

goldLicense: cc-by

publisherhttps://doi.org/10.3390/cells13171479

publisherhttps://www.mdpi.com/2073-4409/13/17/1479/pdf

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11394257

repositoryhttps://escholarship.org/uc/item/21h023s1

Europe_PMChttps://europepmc.org/articles/PMC11394257

Fields of Study

0303 health sciences03 medical and health sciencesInduced Pluripotent Stem CellsHumansCardiomyopathy, DilatedLamin Type AMyocytes, CardiacCell DifferentiationHaploinsufficiencyFemaleTranscriptomePericardiumCell LineageSingle-Cell AnalysisGene Expression RegulationMutationAdult

MeSH Terms

PericardiumMyocytes, CardiacHumansCardiomyopathy, DilatedLamin Type ACell DifferentiationGene Expression RegulationCell LineageMutationAdultFemaleInduced Pluripotent Stem CellsHaploinsufficiencySingle-Cell AnalysisTranscriptome

Keywords

Nuclear laminaDifferentially expressed genesPluripotencyEpigeneticsgenomic imprintingStem CellsX-inactivationCell FateDisease ModelingSingle-cell Rna-seqBiomedical and clinical sciencesHaploinsufficiencyCardiovascularRegenerative MedicineDilated2.1 Biological and endogenous factorsMyocytes, CardiacPediatricStem Cell Research - Induced Pluripotent Stem Cell - HumanCell DifferentiationBiological SciencesLamin Type AHeart DiseaseFemaleSingle-Cell AnalysisCardiacPericardiumCardiomyopathy, DilatedAdult570CardiomyopathyInduced Pluripotent Stem Cells610ArticleRare DiseasesGeneticsHumansCell LineageMyocytesStem Cell Research - Induced Pluripotent Stem CellQH573-671Human GenomeStem Cell ResearchGood Health and Well BeingGene Expression RegulationMutationCytologyTranscriptome

LMNA-Related Dilated Cardiomyopathy: Single-Cell Transcriptomics during Patient-Derived iPSC Differentiation Support Cell Type and Lineage-Specific Dysregulation of Gene Expression and Development for Cardiomyocytes and Epicardium-Derived Cells with Lamin A/C Haploinsufficiency

FAIR Checklist

Authors (8)

Funding (7 grants)

Open Access

Topics

Annotations (Europe PMC)