Alternative Splicing and Isoforms: From Mechanisms to Diseases is a research paper published in Genes (2022). On theSindex it has a DataRank of 2.6. It has been cited 147 times, with 146 citing works in its 1-hop citation network.
Alternative splicing of pre-mRNA is a key mechanism for increasing the complexity of proteins in humans, causing a diversity of expression of transcriptomes and proteomes in a tissue-specific manner. Alternative splicing is regulated by a variety of splicing factors. However, the changes and errors of splicing regulation caused by splicing factors are strongly related to many diseases, something which represents one of this study’s main interests. Further understanding of alternative splicing regulation mediated by cellular factors is also a prospective choice to develop specific drugs for targeting the dynamic RNA splicing process. In this review, we firstly concluded the basic principle of alternative splicing. Afterwards, we showed how splicing isoforms affect physiological activities through specific disease examples. Finally, the available treatment methods relative to adjusting splicing activities have been summarized.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.750
From this paper's citation signal
Citation Network Contribution
1.8
From 99 citing papers with measurable signal
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 29% comes from its base citations and 71% from the citation network (99 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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