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Metformin Reduces Oxidative Damage in RNASEH2-Mutant Aicardi-Goutières Cells

Genes(2025)10.3390/genes16080922Source: DataRank Database

Metformin Reduces Oxidative Damage in RNASEH2-Mutant Aicardi-Goutières Cells is a research paper published in Genes (2025). On theSindex it has a DataRank of 0.

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (4 grants)Impact (FWCI 0.00)OA: goldTopics (63)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Jessica Garau ORCID,Bartolo Rizzo ORCID,Simona Orcesi ORCID,Costanza Varesio ORCID,Rosalinda Di Gerlando ORCID

Live enrichment

PubMed:40869969 PMC:PMC12385763 OpenAlex:https://openalex.org/W4412750929

NIH

Grant: U01NS106845-01A1

NINDS NIH HHS

Grant: U01 NS106845

Ministero della Salute

Grant: Ricerca Corrente 2022-2024

National Institutes of Health

Grant: 1U01NS106845-01A1

Clinical Outcomes in Aicardi Goutières Syndrome

FWCI

0.00

Citation Percentile

0.1%

goldLicense: cc-by

journalhttps://www.mdpi.com/2073-4425/16/8/922/pdf?version=1753883539

publisherhttps://www.mdpi.com/2073-4425/16/8/922/pdf?version=1753883539

publisherhttps://www.mdpi.com/2073-4425/16/8/922/pdf

journalhttps://doi.org/10.3390/genes16080922

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40869969

Fields of Study

interferon and immune responsesCytokine Signaling Pathways and InteractionsSystemic Lupus Erythematosus Research0303 health sciences03 medical and health sciencesHumansMetforminOxidative StressAutoimmune Diseases of the Nervous SystemNervous System MalformationsRibonuclease HReactive Oxygen SpeciesMutationForkhead Box Protein O3MitochondriaMembrane Potential, MitochondrialCell LineAicardi-Goutieres syndrome

MeSH Terms

Forkhead Box Protein O3Cell LineHumansMetforminMitochondriaMutationNervous System MalformationsRibonuclease HReactive Oxygen SpeciesOxidative StressAutoimmune Diseases of the Nervous SystemMembrane Potential, Mitochondrial

Keywords

Oxidative stressMetforminSOD2Reactive oxygen speciesMitochondrial ROSBiologySOD1FOXO3Downregulation and upregulationCancer researchCell biologySuperoxide dismutasePharmacologySignal transductionEndocrinologyDiabetes mellitusBiochemistryGeneProtein kinase BMitochondriaROSRnaseh2Aicardi-goutières SyndromeMembrane Potential, MitochondrialRibonuclease HForkhead Box Protein O3Aicardi-Goutières Syndrome; metformin; mitochondria; oxidative stress; RNASEH2; ROS;Nervous System MalformationsArticleCell LineAutoimmune Diseases of the Nervous SystemMutationHumans