Base Excision Repair in Physiology and Pathology of the Central Nervous System is a research paper published in International Journal of Molecular Sciences (2012). On theSindex it has a DataRank of 1.2. It has been cited 26 times, with 20 citing works in its 1-hop citation network.
Relatively low levels of antioxidant enzymes and high oxygen metabolism result in formation of numerous oxidized DNA lesions in the tissues of the central nervous system. Accumulation of damage in the DNA, due to continuous genotoxic stress, has been linked to both aging and the development of various neurodegenerative disorders. Different DNA repair pathways have evolved to successfully act on damaged DNA and prevent genomic instability. The predominant and essential DNA repair pathway for the removal of small DNA base lesions is base excision repair (BER). In this review we will discuss the current knowledge on the involvement of BER proteins in the maintenance of genetic stability in different brain regions and how changes in the levels of these proteins contribute to aging and the onset of neurodegenerative disorders.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.494
From this paper's citation signal
Citation Network Contribution
0.697
From 20 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 41% comes from its base citations and 59% from the citation network (20 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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