ESCRT Function in Cytokinesis: Location, Dynamics and Regulation by Mitotic Kinases
ESCRT Function in Cytokinesis: Location, Dynamics and Regulation by Mitotic Kinases is a research paper published in International Journal of Molecular Sciences (2014). On theSindex it has a DataRank of 1.4. It has been cited 36 times, with 30 citing works in its 1-hop citation network.
Abstract
Mammalian cytokinesis proceeds by constriction of an actomyosin ring and furrow ingression, resulting in the formation of the midbody bridge connecting two daughter cells. At the centre of the midbody resides the Flemming body, a dense proteinaceous ring surrounding the interlocking ends of anti-parallel microtubule arrays. Abscission, the terminal step of cytokinesis, occurs near the Flemming body. A series of broad processes govern abscission: the initiation and stabilisation of the abscission zone, followed by microtubule severing and membrane scission—The latter mediated by the endosomal sorting complex required for transport (ESCRT) proteins. A key goal of cell and developmental biologists is to develop a clear understanding of the mechanisms that underpin abscission, and how the spatiotemporal coordination of these events with previous stages in cell division is accomplished. This article will focus on the function and dynamics of the ESCRT proteins in abscission and will review recent work, which has begun to explore how these complex protein assemblies are regulated by the cell cycle machinery.
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FAIR Checklist
Context only (not used in score)- Has DOI
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
DataRank Breakdown
Base Score Contribution
0.542
From this paper's citation signal
Citation Network Contribution
0.847
From 26 citing papers with measurable signal
Top 5 citers driving the network score
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
- Midbody assembly and its regulation during cytokinesisMolecular Biology of the Cell2012255 citationsDataRank 9.6
- Distinct roles of septins in cytokinesis: SEPT9 mediates midbody abscissionJournal of Cell Biology2010234 citationsDataRank 8.9
- Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscissionJournal of Cell Biology2010149 citationsDataRank 5.7
- ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4Nature Cell Biology2014132 citationsDataRank 4.8
- A Structural View on ESCRT-Mediated AbscissionFrontiers in Cell and Developmental Biology202012 citationsDataRank 0.641
Why this DataRank?
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 39% comes from its base citations and 61% from the citation network (26 citing papers contributed measurable signal).
- Base score B(p)
- log1p(citation_count) — grows sub-linearly, so a paper with 1,000 citations is not 10× a paper with 100.
- Network N(p)
- Σ over citers of log1p(Cq) ÷ max(outdegreeq, 1). Being cited by a highly-cited paper with few references counts most.
- Damping factor d = 0.85
- DataRank = (1−d)·B(p) + d·N(p) — the two cards above are each already multiplied by their share.
- Self-citations excluded
- Citers sharing any OpenAlex author ID with this paper are filtered out before the network sum.
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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