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Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation

International Journal of Molecular Sciences(2020)10.3390/ijms21249557Source: DataRank Database

Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation is a research paper published in International Journal of Molecular Sciences (2020). On theSindex it has a DataRank of 0. It has been cited 13 times.

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Enrichment:Funding (2 grants)OA: goldTopics (43)IDs (PubMed, PMC)Annotations (2)SDGs (1)

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Authors (8)

Sang Hyo Bae,R. Jason Kirby,Martina Fitzek,Preeti Iyer ORCID,Ola Engkvist ORCID

Live enrichment

PubMed:33334026 PMC:PMC7765409

National Institutes of Health

Grant: DK101520

National Institutes of Health

Grant: 5R01DK101520-03

Identification of Rev-Erb alpha/beta nuclear receptor modulators

goldLicense: CC BY

Unpaywallhttps://www.mdpi.com/1422-0067/21/24/9557/pdf?version=1608109173

Europe_PMChttps://europepmc.org/articles/PMC7765409

Europe_PMChttps://europepmc.org/articles/PMC7765409?pdf=render

https://doi.org/10.3390/ijms21249557

https://www.mdpi.com/1422-0067/21/24/9557/pdf

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

LiverHepatocytesAnimalsHumansCCAAT-Enhancer-Binding ProteinsProtein Kinase InhibitorsDrug Screening Assays, AntitumorComputational BiologySignal TransductionLipid MetabolismDiacylglycerol O-AcyltransferaseCyclin-Dependent Kinase 2Induced Pluripotent Stem CellsHigh-Throughput Nucleotide SequencingEndoplasmic Reticulum StressLipid Droplets

Keywords

lipid dropletsdrug discoverySteatosisNafldOpen InnovationHuman Induced Pluripotent Stem Cell-derived HepatocytesCdk4-c/ebpα/dgat2 PathwayChemogenomic Library ScreeningQuantitative High-content Microscopy AnalysisInduced Pluripotent Stem CellsArticleAnimalsHumansDiacylglycerol O-AcyltransferaseProtein Kinase InhibitorsCyclin-Dependent Kinase 2Computational BiologyHigh-Throughput Nucleotide SequencingEndoplasmic Reticulum StressLipid MetabolismLiverCCAAT-Enhancer-Binding ProteinsHepatocytesDrug Screening Assays, AntitumorSignal Transduction

Sustainable Development Goals

SDG 3: 3. Good health

Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation

FAIR Checklist

Authors (8)

Funding (2 grants)

Open Access

Topics

Annotations (Europe PMC)