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Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells

International Journal of Molecular Sciences(2021)10.3390/ijms22136676Source: DataRank Database

Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells is a research paper published in International Journal of Molecular Sciences (2021). On theSindex it has a DataRank of 0. It has been cited 12 times.

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Open Access12 citations

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Enrichment:Funding (6 grants)Impact (FWCI 0.57)OA: goldTopics (50)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Yiwei Li ORCID,Husain Yar Khan ORCID,Irfana Muqbil ORCID,Amro Aboukameel,Rachel Sexton ORCID

Live enrichment

PubMed:34206543 PMC:PMC8268282 OpenAlex:https://openalex.org/W3175656263

National Institutes of Health

Grant: 5P50CA186786-07

Michigan Prostate SPORE

National Institutes of Health

Grant: P30CA022453

National Institutes of Health

Grant: R37CA215427

NCI NIH HHS

Grant: P50 CA186786

National Institutes of Health

Grant: 3P30CA022453-37S2

Cancer Center Support Grant

National Institutes of Health

Grant: 5R37CA215427-04

Clinical Translation of Nuclear Export Inhibitor in Metastatic Pancreatic Cancer

FWCI

0.57

Citation Percentile

0.7%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://www.mdpi.com/1422-0067/22/13/6676/pdf?version=1624956819

publisherhttps://www.mdpi.com/1422-0067/22/13/6676/pdf?version=1624956819

publisherhttps://www.mdpi.com/1422-0067/22/13/6676/pdf

journalhttps://doi.org/10.3390/ijms22136676

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34206543

Fields of Study

PARP inhibition in cancer therapyProstate Cancer Treatment and ResearchNuclear Structure and Function0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Poly(ADP-ribose) Polymerase InhibitorsAntineoplastic AgentsDrug SynergismHumansMaleModels, BiologicalApoptosisActive Transport, Cell NucleusCell Line, TumorCell ProliferationApoptosis Regulatory ProteinsProstatic Neoplasms, Castration-Resistant

Keywords

OlaparibCancer researchPARP inhibitorProstate cancerApoptosisPoly ADP ribose polymeraseVeliparibChemistryDownregulation and upregulationCancerInternal medicineMedicineBiochemistryDNAGeneNuclear ExportParp InhibitorsCastration ResistanceKpt-8602EltanexorMaleActive Transport, Cell NucleusAntineoplastic AgentsDrug SynergismPoly(ADP-ribose) Polymerase InhibitorsModels, BiologicalArticleProstatic Neoplasms, Castration-ResistantCell Line, TumorHumansApoptosis Regulatory ProteinsCell Proliferation

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells

FAIR Checklist

Authors (11)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)