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Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets

International Journal of Molecular Sciences(2021)10.3390/ijms222011256Source: DataRank Database

Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets is a research paper published in International Journal of Molecular Sciences (2021). On theSindex it has a DataRank of 0. It has been cited 11 times.

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0DataRank · unranked

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Open Access11 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (5 grants)Impact (FWCI 0.68)OA: goldTopics (83)IDs (PubMed, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Breana Laguera ORCID,Sunena Chandra,Ramesh Dasari,Wesley J. Olivier ORCID,Jason A. Smith ORCID

Live enrichment

PubMed:34681916 OpenAlex:https://openalex.org/W3206168605

National Institutes of Health

Grant: 5R21GM131717-02

Tandem Discovery of Drug Leads and Targets via Paal-Knorr reaction

National Institutes of Health

Grant: 1R15CA227680-01A1

Acid-Sensitive Glioblastoma Prodrugs Derived from Ophiobolin A

NIGMS NIH HHS

Grant: R25 GM102783

NIGMS NIH HHS

Grant: R21 GM131717

NCI NIH HHS

Grant: R15 CA227680

FWCI

0.68

Citation Percentile

0.6%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://www.mdpi.com/1422-0067/22/20/11256/pdf?version=1634727337

publisherhttps://www.mdpi.com/1422-0067/22/20/11256/pdf?version=1634727337

publisherhttps://www.mdpi.com/1422-0067/22/20/11256/pdf

journalhttps://doi.org/10.3390/ijms222011256

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34681916

Fields of Study

Synthetic Organic Chemistry MethodsMicrobial Natural Products and BiosynthesisMarine Sponges and Natural Products0301 basic medicine03 medical and health sciences0303 health sciencesA549 CellsAnimalsAntineoplastic AgentsCell Line, TumorCell ProliferationCell SurvivalDrug Screening Assays, AntitumorHumansMCF-7 CellsMiceMolecular StructureSesquiterpenesSesterterpenesStructure-Activity RelationshipTerpenes

MeSH Terms

A549 CellsAnimalsAntineoplastic AgentsCell SurvivalDrug Screening Assays, AntitumorHumansSesquiterpenesStructure-Activity RelationshipTerpenesMolecular StructureCell Line, TumorCell ProliferationMiceSesterterpenesMCF-7 Cells

Keywords

ApoptosisCancer cellChemistryAmine gas treatingBiochemistryCovalent bondCancerStereochemistryCombinatorial chemistryBiologyComputational biologyOrganic chemistryGeneticsophiobolin ASesterterpenesCell Survivalpolygodialacoustique]Informatique appliquée logicielAntineoplastic AgentsChimie inorganiqueAnticancer activityPhysico-chimie généraleapoptosis resistanceMiceStructure-Activity RelationshipCell Line, TumorSpectroscopie [électromagnétismeAnimalsHumansWittig reactionoptiqueSpectroscopie [état condense]Cell ProliferationMolecular StructureTerpenesCommunicationBiologie moléculaireChimie théoriqueWittig reaction; anticancer activity; apoptosis resistance; ophiobolin A; polygodialChimie organiqueSpectroscopie [électromagnétisme, optique, acoustique]A549 CellsMCF-7 CellsDrug Screening Assays, AntitumorCatalyses hétérogène et homogèneSesquiterpenes

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being