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Alpha-1 Antitrypsin Inhibits Tumorigenesis and Progression of Colitis-Associated Colon Cancer through Suppression of Inflammatory Neutrophil-Activated Serine Proteases and IGFBP-3 Proteolysis

International Journal of Molecular Sciences(2022)10.3390/ijms232213737Source: DataRank Database

Alpha-1 Antitrypsin Inhibits Tumorigenesis and Progression of Colitis-Associated Colon Cancer through Suppression of Inflammatory Neutrophil-Activated Serine Proteases and IGFBP-3 Proteolysis is a research paper published in International Journal of Molecular Sciences (2022). On theSindex it has a DataRank of 0. It has been cited 16 times.

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Open Access16 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 1.75)OA: goldTopics (66)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (7)

Min Sun Kim ORCID,Aki Harada,Michael O. Idowu ORCID,Gobalakrishnan Sundaresan ORCID,Jamal Zweit ORCID

Live enrichment

PubMed:36430216 PMC:PMC9698049 OpenAlex:https://openalex.org/W4308718502

National Cancer Institute award

Grant: 1R21CA216685-01A1

Therapeutic potential of neutrophil protease inhibitors in colon cancer

National Cancer Institute award

Grant: P30 CA016059

NCI NIH HHS

Grant: R21 CA216685

National Institutes of Health

Grant: 4P30CA016059-35

Massey Cancer Center Support Grant

VCU Massey Cancer Center DT award

Virginia Commonwealth University Cancer Mouse Models Core Laboratory

FWCI

1.75

Citation Percentile

0.9%

Citation Trend

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://www.mdpi.com/1422-0067/23/22/13737/pdf?version=1667920901

publisherhttps://www.mdpi.com/1422-0067/23/22/13737/pdf?version=1667920901

publisherhttps://www.mdpi.com/1422-0067/23/22/13737/pdf

journalhttps://doi.org/10.3390/ijms232213737

repositoryhttps://pubmed.ncbi.nlm.nih.gov/36430216

Fields of Study

Growth Hormone and Insulin-like Growth FactorsTGF-β signaling in diseasesProtease and Inhibitor Mechanisms0301 basic medicine03 medical and health sciences0303 health sciencesMiceAnimalsColitis-Associated NeoplasmsNeutrophilsInsulin-Like Growth Factor Binding Protein 3Serine ProteasesProteolysisDextran Sulfatealpha 1-Antitrypsin DeficiencyCarcinogenesisCell Transformation, NeoplasticInflammationSerine Endopeptidases

MeSH Terms

Colitis-Associated NeoplasmsAnimalsCell Transformation, NeoplasticInflammationNeutrophilsSerine EndopeptidasesDextran SulfateInsulin-Like Growth Factor Binding Protein 3alpha 1-Antitrypsin DeficiencyMiceSerine ProteasesProteolysisCarcinogenesis

Keywords

ProteasesInflammationProteolysisCarcinogenesisColitisCancer researchProinflammatory cytokineCancerSerineImmunologyMedicineChemistryInternal medicineBiochemistryEnzymeAntitumorIGFBP-3Anti-inflammationneutrophilColitis-associated Colon CancerAatNspsIgfbp-3rNeutrophilsArticleMicealpha 1-Antitrypsin DeficiencyAnimalsDextran SulfateSerine EndopeptidasesInsulin-Like Growth Factor Binding Protein 3Cell Transformation, NeoplasticColitis-Associated NeoplasmsSerine Proteases

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being