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A Dual-Function “TRE-Lox” System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D

International Journal of Molecular Sciences(2023)10.3390/ijms24076745Source: DataRank Database

A Dual-Function “TRE-Lox” System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D is a research paper published in International Journal of Molecular Sciences (2023). On theSindex it has a DataRank of 0. It has been cited 2 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access2 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 0.19)OA: goldTopics (49)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Derek S. Maranan,Luke A. Burgard,Frank M. LaFerla ORCID,Shelley Lane ORCID,Malcolm A. Leissring ORCID

Live enrichment

PubMed:37047718 PMC:PMC10095275 OpenAlex:https://openalex.org/W4362635543

U.S. National Institutes of Health

Grant: R01 AG066928

National Institutes of Health

Grant: 1R01AG066928-01A1

Temporal and spatial aspects of amyloidogenesis in sporadic Alzheimer disease

FWCI

0.19

Citation Percentile

0.4%

Citation Trend

2024

2025

goldLicense: cc-by

journalhttps://www.mdpi.com/1422-0067/24/7/6745/pdf?version=1680613600

publisherhttps://www.mdpi.com/1422-0067/24/7/6745/pdf?version=1680613600

publisherhttps://www.mdpi.com/1422-0067/24/7/6745/pdf

journalhttps://doi.org/10.3390/ijms24076745

repositoryhttps://pubmed.ncbi.nlm.nih.gov/37047718

Fields of Study

CRISPR and Genetic EngineeringRNA Interference and Gene DeliveryInsect Resistance and Genetics0301 basic medicine03 medical and health sciences

MeSH Terms

AnimalsCathepsin DDoxycyclineFibroblastsTetracyclineDown-RegulationResponse ElementsMice

Keywords

Downregulation and upregulationGeneBiologyGene expressionCre-Lox recombinationCell biologyGene targetingPhenotypeMolecular biologyChemistryGeneticsTransgeneGenetically modified mouseGene regulationAlzheimer diseasecathepsin DCrisprCre-lox TechnologyTetracycline Regulatory ElementDown-RegulationResponse ElementsMicrobiologyArticleMiceMedicinal and biomolecular chemistryAnimalsChemical PhysicsBiochemistry and Molecular BiologyBiology and Life SciencesBiological SciencesFibroblastsTetracyclineBiochemistry and cell biologyDoxycyclineOther Biological SciencesOther Chemical Sciences

Sustainable Development Goals

SDG 0: Good health and well-being