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Retina-Targeted 17β-Estradiol by the DHED Prodrug Rescues Visual Function and Actuates Neuroprotective Protein Networks After Optic Nerve Crush in a Rat Model of Surgical Menopause

International Journal of Molecular Sciences(2025)10.3390/ijms26051846Source: DataRank Database

Retina-Targeted 17β-Estradiol by the DHED Prodrug Rescues Visual Function and Actuates Neuroprotective Protein Networks After Optic Nerve Crush in a Rat Model of Surgical Menopause is a research paper published in International Journal of Molecular Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 4 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access4 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (24 grants)Impact (FWCI 6.72)OA: goldTopics (78)IDs (PubMed, PMC, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Khadiza Zaman ORCID,Ammar Kapic ORCID,Kelleigh Hogan,Gabriela Sánchez-Rodríguez,Anna E. Silverio

Live enrichment

PubMed:40076480 PMC:PMC11899211 OpenAlex:https://openalex.org/W4407809625

National Eye Institute National Institutes of Health (NIH)

Grant: EY027005

National Eye Institute National Institutes of Health (NIH)

Grant: EY030871

National Eye Institute National Institutes of Health (NIH)

Grant: EY035468

National Eye Institute National Institutes of Health (NIH)

Grant: BK-0031

National Eye Institute National Institutes of Health (NIH)

Grant: CDA2

National Eye Institute National Institutes of Health (NIH)

Grant: RX002342

National Eye Institute National Institutes of Health (NIH)

Grant: NIH T32 AG020494

National Eye Institute National Institutes of Health (NIH)

Grant: 100010434

National Eye Institute National Institutes of Health (NIH)

Grant: LCF/BQ/EU21/11890105

NIH HHS

Grant: 2R01EY027005-07X1

NEI NIH HHS

Grant: P30 EY006360

NIA NIH HHS

Grant: T32 AG020494

RRD VA

Grant: IK2 RX002342

NEI NIH HHS

Grant: R21 EY035468

NIH HHS

Grant: P30 EY06360

NEI NIH HHS

Grant: R01 EY027005

"La Caixa" Foundation Fellowship

Grant: 100010434 - LCF/BQ/EU21/11890105

NEI NIH HHS

Grant: R01 EY030871

NIH HHS

Grant: T32 AG02049

National Institutes of Health

Grant: 3R01EY027005-03S2

A Novel Neuroprotective Approach for Glaucoma

National Institutes of Health

Grant: 5R01EY030871-02

Impact of Menopause on the Aqueous Outflow Pathway

National Institutes of Health

Grant: 2P30EY006360-06

CORE GRANT--DEPARTMENT OF OPHTHALMOLOGY

National Institutes of Health

Grant: 5T32AG020494-13

Training in the Neurobiology of Aging

National Institutes of Health

Grant: 1R21EY035468-01

Assessing the Impact of Age, Sex, and Menopause on Scleral Biomechanics and Gene Expression

FWCI

6.72

Citation Percentile

1.0%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://www.mdpi.com/1422-0067/26/5/1846/pdf?version=1740135600

publisherhttps://www.mdpi.com/1422-0067/26/5/1846/pdf?version=1740135600

publisherhttps://www.mdpi.com/1422-0067/26/5/1846/pdf

journalhttps://doi.org/10.3390/ijms26051846

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40076480

Fields of Study

Glaucoma and retinal disordersRetinal Diseases and TreatmentsCorneal surgery and disorders03 medical and health sciences0302 clinical medicineAnimalsFemaleEstradiolRatsProdrugsNeuroprotective AgentsOvariectomyRetinaOptic Nerve InjuriesDisease Models, AnimalRetinal Ganglion CellsMenopauseNerve CrushOptic NerveProteomicsGlaucomaTomography, Optical Coherence

MeSH Terms

AnimalsDisease Models, AnimalEstradiolFemaleGlaucomaMenopauseNerve CrushOptic NerveOvariectomyProdrugsRats, Inbred BNRetinaRetinal Ganglion CellsVision, OcularNeuroprotective AgentsOptic Nerve InjuriesProteomicsTomography, Optical CoherenceRatsProtein Interaction Maps

Keywords

Optic nerveNeuroprotectionRetinaRetinal ganglion cellRetinalGlaucomaMedicineNeurodegenerationNeuroscienceOphthalmologyEndocrinologyInternal medicineBiologyDiseaseEstrogenBioinformaticsmenopauseOptomotor Responseoptic nerve crushProtein–protein Interaction NetworksDhedQuantitative Label-free Retina ProteomicsRetinal Ganglion CellsProteomicsNerve CrushOvariectomyArticleAnimalsProdrugsEstradiolRatsDisease Models, AnimalNeuroprotective AgentsOptic Nerve InjuriesFemaleTomography, Optical Coherence

Sustainable Development Goals

SDG 0: Good health and well-being