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Preclinical Efficacy of the Estrogen Receptor Degrader Fulvestrant in Combination with RAF/MEK Clamp Avutometinib and FAK Inhibitor in a Low-Grade Serous Ovarian Cancer Animal Model with Acquired Resistance to Chemotherapy and Aromatase Inhibitor

International Journal of Molecular Sciences(2025)10.3390/ijms26188924Source: DataRank Database

Preclinical Efficacy of the Estrogen Receptor Degrader Fulvestrant in Combination with RAF/MEK Clamp Avutometinib and FAK Inhibitor in a Low-Grade Serous Ovarian Cancer Animal Model with Acquired Resistance to Chemotherapy and Aromatase Inhibitor is a research paper published in International Journal of Molecular Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Enrichment:Funding (7 grants)Impact (FWCI 1.89)OA: goldTopics (51)IDs (PubMed, PMC, OpenAlex)Annotations (1)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (16)

Stefania Bellone ORCID,Victoria M. Ettorre ORCID,Miranda Mansolf,Tobias M.P. Hartwich ORCID,Blair McNamara ORCID

Live enrichment

PubMed:41009492 PMC:PMC12469703 OpenAlex:https://openalex.org/W4414252470

NIH

Grant: U01 CA176067-01A1

NIH

Grant: CA-16359

NCI NIH HHS

Grant: U01 CA176067

Deborah Bunn Alley Foundation

Grant: N/A

NCI NIH HHS

Grant: P30 CA016359

National Institutes of Health

Grant: 1U01CA176067-01A1

Integrated genomic analysis of racial disparities in endometrial cancer

National Institutes of Health

Grant: 2P30CA016359-15

COMPREHENSIVE CANCER CENTER

FWCI

1.89

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://www.mdpi.com/1422-0067/26/18/8924/pdf?version=1757749366

publisherhttps://www.mdpi.com/1422-0067/26/18/8924/pdf?version=1757749366

publisherhttps://www.mdpi.com/1422-0067/26/18/8924/pdf

journalhttps://doi.org/10.3390/ijms26188924

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41009492

Fields of Study

Ovarian cancer diagnosis and treatmentEstrogen and related hormone effectsAdvanced Breast Cancer Therapies03 medical and health sciences0302 clinical medicine

MeSH Terms

FulvestrantAnimalsAntineoplastic Combined Chemotherapy ProtocolsDisease Models, AnimalFemaleHumansOvarian NeoplasmsReceptors, EstrogenMice, SCIDDrug Resistance, NeoplasmXenograft Model Antitumor AssaysCell Line, TumorAromatase InhibitorsProtein Kinase InhibitorsMiceFocal Adhesion Kinase 1

Keywords

FulvestrantEstrogen receptorIn vivoEx vivoAromatase inhibitorOvarian cancerCombination therapyEstrogenCancerEstrogen receptor alphaMek InhibitorLow-grade Serous Ovarian CancerFak InhibitorAvutometinibOvarian NeoplasmsAromatase InhibitorsMice, SCIDXenograft Model Antitumor AssaysArticleMiceDisease Models, AnimalReceptors, EstrogenDrug Resistance, NeoplasmCell Line, TumorFocal Adhesion Kinase 1Antineoplastic Combined Chemotherapy ProtocolsAnimalsHumansFemaleProtein Kinase Inhibitors

Preclinical Efficacy of the Estrogen Receptor Degrader Fulvestrant in Combination with RAF/MEK Clamp Avutometinib and FAK Inhibitor in a Low-Grade Serous Ovarian Cancer Animal Model with Acquired Resistance to Chemotherapy and Aromatase Inhibitor

FAIR Checklist

Authors (16)

Funding (7 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)