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Standardized Saponin Extract from Baiye No.1 Tea (Camellia sinensis) Flowers Induced S Phase Cell Cycle Arrest and Apoptosis via AKT-MDM2-p53 Signaling Pathway in Ovarian Cancer Cells

Molecules(2020)10.3390/molecules25153515Source: DataRank Database

Standardized Saponin Extract from Baiye No.1 Tea (Camellia sinensis) Flowers Induced S Phase Cell Cycle Arrest and Apoptosis via AKT-MDM2-p53 Signaling Pathway in Ovarian Cancer Cells is a research paper published in Molecules (2020). On theSindex it has a DataRank of 0. It has been cited 37 times.

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Enrichment:Funding (6 grants)Impact (FWCI 1.90)OA: goldTopics (85)Linked Datasets (4)DataCite Reuse (4)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

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Accessible (1/2)

Open Access

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Authors (9)

Lianfu Chen,Ning Ren ORCID,Bo Li ORCID,Yuanyuan Wu ORCID,Gary O. Rankin ORCID

Live enrichment

PubMed:32752095 PMC:PMC7435957 OpenAlex:https://openalex.org/W3046790939

National Institutes of Health

Grant: P20GM103434

NIGMS NIH HHS

Grant: U54 GM104942

National Health and Medical Research Council (NHMRC)

Grant: 104932

BIOLOGICAL STUDIES OF A NEW RECURRENT FUSION GENE FOUND IN T-CELL LEUKAEMIA

National Institutes of Health

Grant: 5P20GM103434-16

West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)

National Institutes of Health

Grant: 5P20RR016477-03

The Appalachian Cardiovascular Research Network

National Institutes of Health

Grant: 5P20GM104932-09

Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)

FWCI

1.90

Citation Percentile

0.9%

Citation Trend

2014

2020

2021

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://www.mdpi.com/1420-3049/25/15/3515/pdf

publisherhttps://www.mdpi.com/1420-3049/25/15/3515/pdf

journalhttps://doi.org/10.3390/molecules25153515

repositoryhttps://pubmed.ncbi.nlm.nih.gov/32752095

repositoryhttps://doaj.org/article/f7f07c87ab81465f8bb9db2874efd92b

Fields of Study

Cancer-related Molecular PathwaysNatural product bioactivities and synthesisCancer, Lipids, and Metabolism0301 basic medicine03 medical and health sciences0303 health sciencesApoptosisCamellia sinensisCell Line, TumorCell SurvivalCyclin A2Cyclin-Dependent Kinase Inhibitor p27FemaleFlowersGene Expression RegulationHumansOleanolic AcidOvarian NeoplasmsPlant ExtractsProliferating Cell Nuclear AntigenProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-mdm2S Phase Cell Cycle CheckpointsSaponinsSignal TransductionTumor Suppressor Protein p53

MeSH Terms

Cell SurvivalFemaleGene Expression RegulationHumansOleanolic AcidOvarian NeoplasmsPlant ExtractsSaponinsSignal TransductionTumor Suppressor Protein p53ApoptosisProliferating Cell Nuclear AntigenCamellia sinensisFlowersCell Line, TumorCyclin-Dependent Kinase Inhibitor p27Proto-Oncogene Proteins c-aktProto-Oncogene Proteins c-mdm2Cyclin A2S Phase Cell Cycle Checkpoints

Keywords

ApoptosisCell cycleProtein kinase BBiologyPI3K/AKT/mTOR pathwayCell cycle checkpointSignal transductionCancer researchCell growthG1 phaseBiochemistryCell biologyChemistryS Phase Cell Cycle ArrestA2780/cp70 Ovarian Cancer CellsBtfsTea (Camellia Sinensis) FlowersCell SurvivalOrganic chemistryFlowersArticleCamellia sinensisQD241-441Cell Line, TumorProliferating Cell Nuclear AntigenHumansOleanolic AcidOvarian NeoplasmsPlant ExtractsProto-Oncogene Proteins c-mdm2Saponinstea (<i>Camellia sinensis</i>) flowersGene Expression RegulationS Phase Cell Cycle CheckpointsFemaleTumor Suppressor Protein p53Cyclin A2Proto-Oncogene Proteins c-aktCyclin-Dependent Kinase Inhibitor p27

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Additional file 1 of d-Borneol enhances cisplatin sensitivity via p21/p27-mediated S-phase arrest and cell apoptosis in non-small cell lung cancer cells and a murine xenograft model

10.6084/m9.figshare.20381944.v1figshare

Additional file 1 of d-Borneol enhances cisplatin sensitivity via p21/p27-mediated S-phase arrest and cell apoptosis in non-small cell lung cancer cells and a murine xenograft model

10.6084/m9.figshare.20381944figshare

Additional file 2 of d-Borneol enhances cisplatin sensitivity via p21/p27-mediated S-phase arrest and cell apoptosis in non-small cell lung cancer cells and a murine xenograft model

10.6084/m9.figshare.20381947.v1figshare

Additional file 2 of d-Borneol enhances cisplatin sensitivity via p21/p27-mediated S-phase arrest and cell apoptosis in non-small cell lung cancer cells and a murine xenograft model

10.6084/m9.figshare.20381947figshare

Standardized Saponin Extract from Baiye No.1 Tea (Camellia sinensis) Flowers Induced S Phase Cell Cycle Arrest and Apoptosis via AKT-MDM2-p53 Signaling Pathway in Ovarian Cancer Cells

FAIR Checklist

Authors (9)

Funding (6 grants)

Impact

Open Access

Topics

Linked Datasets (4)

Annotations (Europe PMC)